2-BroMo-5-Methylnicotinonitrile

Base Information

• Chemical Name: 2-BroMo-5-Methylnicotinonitrile
• CAS No.: 65996-18-1
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.032
• Hs Code.: 2933399090
• Mol file: 65996-18-1.mol

Synonyms:2-BroMo-5-Methylnicotinonitrile

Chemical Property of 2-BroMo-5-Methylnicotinonitrile

Chemical Property:

• Boiling Point: 319.3±42.0 °C(Predicted)
• PKA: -2.36±0.20(Predicted)
• PSA: 36.68000
• Density: 1.61±0.1 g/cm3(Predicted)
• LogP: 2.02418
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-methylnicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-5-Methylnicotinonitrile

There total 6 articles about 2-BroMo-5-Methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-2-(3-(dimethylamino)-2-methylallylidene)malononitrile (124571-68-2) → 2-bromo-5-methylnicotinonitrile (65996-18-1)

Guidance literature:

With hydrogen bromide; In acetic acid; at 55 ℃; for 0.75h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01169

Reference yield: 60.0%

2-methoxy-5-methylpyridine-3-carbonitrile (149379-73-7) → 2-bromo-5-methylnicotinonitrile (65996-18-1)

Guidance literature:

With phosphoric acid; Pyridine hydrobromide; phosphorus(V) oxybromide; In benzene; for 96h; Heating;

Reference yield: 15.0%

1,1-dicyano-4-ethoxy-3-methyl-1,3-butadiene (65995-93-9) → 2-bromo-5-methylnicotinonitrile (65996-18-1)

Guidance literature:

upstream raw materials:

2-methoxy-5-methylpyridine-3-carbonitrile

1,1-dicyano-4-ethoxy-3-methyl-1,3-butadiene

propylidenemalonitrile

(E)-2-(3-(dimethylamino)-2-methylallylidene)malononitrile

Refernces

• 1、 Longstreet, Ashley R.,Campbell, Brian S.,Gupton, B. Frank,McQuade, D. Tyler. "Improved synthesis of mono- and disubstituted 2-halonicotinonitriles from alkylidene malononitriles". . p. 5298 - 5301. Retrieved 2013/11/06.
• 2、 -. "Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines". . . Retrieved 2008/06/13.