6-Desfluoro-6-hydroxy Risperidone

Base Information

• Chemical Name: 6-Desfluoro-6-hydroxy Risperidone
• CAS No.: 106266-11-9
• Molecular Formula: C₂₃H₂₈N₄O₃
• Molecular Weight: 408.5
• Mol file: 106266-11-9.mol

Synonyms:6-Desfluoro-6-hydroxy Risperidone;6,7,8,9-Tetrahydro-3-[2-[4-(6-hydroxy-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-Methyl-4H-pyrido[1,2-a]pyriMidin-4-one

Chemical Property of 6-Desfluoro-6-hydroxy Risperidone

Chemical Property:

• Vapor Pressure: 1.12E-15mmHg at 25°C
• Melting Point: 247-250°C
• Boiling Point: 614.2°C at 760 mmHg
• Flash Point: 325.2°C
• PSA: 84.39000
• Density: 1.4g/cm³
• LogP: 3.09480
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly, Heated), Methanol (Very Slightly)

Purity/Quality:

97% ^*data from raw suppliers

6-Desfluoro-6-hydroxyRisperidone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A Risperidone derivative. An impurity of Risperidone (R525000).

Technology Process of 6-Desfluoro-6-hydroxy Risperidone

There total 2 articles about 6-Desfluoro-6-hydroxy Risperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (63234-80-0) + 3-(piperidin-4-yl)benzo[d]isoxazol-6-ol (1569268-45-6) → 3-(2-(4-(6-hydroxybenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (106266-11-9)

Guidance literature:

With sodium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

→ 3-(2-(4-(6-hydroxybenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (106266-11-9)

Guidance literature:

upstream raw materials:

3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

3-(piperidin-4-yl)benzo[d]isoxazol-6-ol