2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Base Information

Chemical Name:2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate
CAS No.:1462950-49-7
Molecular Formula:C₂₁H₃₄N₂O₃
Molecular Weight:362.513
Hs Code.:
Mol file:1462950-49-7.mol

Synonyms:2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Suppliers and Price of 2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of 2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

There total 5 articles about 2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1462950-49-7
2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 1.5 h / 85 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 4.5 h / 90 °C

3: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

4: palladium 10% on activated carbon; ammonium formate / methanol / 5 h / 80 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonium formate; potassium acetate; sodium carbonate; caesium carbonate; lithium chloride; In 1,4-dioxane; methanol;

Reference yield:

: 1462950-52-2
2-methylpropan-2-yl 6-ethyl-4-[4-nitro-3-(propan-2-yloxy)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate

: 1462950-49-7
2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In methanol; at 80 ℃; for 5h; Microwave irradiation;

Reference yield:

: 324769-07-5
tert-butyl 2-ethyl-4-oxopiperidine-1-carboxylate

: 1462950-49-7
2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 16 h / 20 °C

2.1: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; ammonium formate / methanol / 5 h / 80 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium 10% on activated carbon; ammonium formate; sodium carbonate; diisopropylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane;