Technology Process of 2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate
There total 5 articles about 2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate / 1.5 h / 85 °C
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 4.5 h / 90 °C
3: lithium chloride; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere
4: palladium 10% on activated carbon; ammonium formate / methanol / 5 h / 80 °C / Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; ammonium formate; potassium acetate; sodium carbonate; caesium carbonate; lithium chloride;
In
1,4-dioxane; methanol;
- Guidance literature:
-
With
palladium 10% on activated carbon; ammonium formate;
In
methanol;
at 80 ℃;
for 5h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 16 h / 20 °C
2.1: lithium chloride; tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; ammonium formate / methanol / 5 h / 80 °C / Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; palladium 10% on activated carbon; ammonium formate; sodium carbonate; diisopropylamine; lithium chloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane;