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Technology Process of 1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea

1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea

Base Information Edit
  • Chemical Name:1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
  • CAS No.:383150-41-2
  • Molecular Formula:C17H19Cl2N7O
  • Molecular Weight:408.29
  • Hs Code.:
  • European Community (EC) Number:663-469-6
  • DSSTox Substance ID:DTXSID60436982
  • Nikkaji Number:J2.505.951D
  • Wikidata:Q82252334
  • Pharos Ligand ID:ZBNNZYBGGS69
  • ChEMBL ID:CHEMBL1368758
  • Mol file:383150-41-2.mol
1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea

Synonyms:JTE 013;JTE-013;JTE013

Suppliers and Price of 1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • JTE013
  • 10mg
  • $ 155.00
  • TRC
  • JTE013
  • 25mg
  • $ 310.00
  • Sigma-Aldrich
  • JTE-013 ≥98% (HPLC)
  • 5mg
  • $ 124.00
  • Sigma-Aldrich
  • JTE-013 ≥98% (HPLC)
  • 25mg
  • $ 495.00
  • DC Chemicals
  • JTE-013 >98%
  • 1 g
  • $ 1450.00
  • DC Chemicals
  • JTE-013 >98%
  • 100 mg
  • $ 450.00
  • Crysdot
  • JTE013 98%
  • 10mg
  • $ 92.00
  • Crysdot
  • JTE013 98%
  • 5mg
  • $ 76.00
  • Crysdot
  • JTE013 98%
  • 50mg
  • $ 441.00
  • ChemScene
  • JTE-013 99.57%
  • 50mg
  • $ 450.00
Total 21 raw suppliers
Chemical Property of 1-(2,6-Dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea Edit
Chemical Property:
  • PKA:9.32±0.43(Predicted) 
  • PSA：96.76000 
  • Density:1.50±0.1 g/cm3(Predicted) 
  • LogP:4.78740 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: ≥20mg/mL 
  • XLogP3:4.4
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:4
  • Exact Mass:407.1028136
  • Heavy Atom Count:27
  • Complexity:516
Purity/Quality:

97% *data from raw suppliers

JTE013 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:T 
  • Statements: 25 
  • Safety Statements: 45 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=NN(C2=C1C(=CC(=N2)NNC(=O)NC3=CC(=NC(=C3)Cl)Cl)C(C)C)C
  • Description Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. JTE-013 is a potent, selective sphingosine-1-phosphate 2 (S1P2) receptor antagonist that binds to the human and rat receptors with IC50 values of 17 and 22 nM, respectively, (IC50 values >10 μM for human S1P1 and S1P3). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-013 inhibits S1P-induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.
  • Uses JTE-013 has been used in in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.

Total 8 Pictures about this product

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