Rifapentine

Base Information

• Chemical Name: Rifapentine
• CAS No.: 61379-65-5
• Molecular Formula: C47H64N4O12
• Molecular Weight: 877.045
• Hs Code.: 3003.20
• Mol file: 61379-65-5.mol

Synonyms:Antibiotic DL 473IT;Cyclopentylrifampicin;DL 473;KTC 1;MDL 473;Prifitin;Priftin;R 77-3;Rifamycin AF/ACPP;

Chemical Property of Rifapentine

Chemical Property:

• Appearance/Colour: Crystalline solid
• Melting Point: 179-180 °C
• Refractive Index: 1.63
• Boiling Point: 969.3±65.0 °C(Predicted)
• PKA: 4.81±0.70(Predicted)
• PSA: 216.66000
• Density: 1.337 g/cm³
• LogP: 5.33450
• Storage Temp.: -20°C Freezer
• Solubility.: methanol: soluble2mg/mL, clear, red to red-brown

Purity/Quality:

99% ^*data from raw suppliers

Rifapentine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Rifapentine is a broad spectrum antibiotic highly active against Gram-positive bacteria and Neisseria gonorrhoea. It is reported to be 10 times more active than the structurally related rifampicin against Mycobacrerim fuberculosis. Unlike rifampicin the bioavailability of rifapentine is significantly increased when administered after a meal.
• Uses: antibacterial (tuberculostatic);'inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis PDE5 inhibitor for erectile dysfunction A semisynthetic ansamycin antibiotic, cyclopentyl derivative of Rifamycin. Treatment of pulmonary tuberculosis Semi-synthetic rifamycin. Antibacterial (tuberculostatic)
• Indications: Rifapentine is an analogue of rifampin that is active against M. tuberculosis and M. avium. Rifapentine’s mechanism of action, cross-resistance, hepatic induction of P450 enzymes, drug interactions, and toxic profile are similar to those of rifampin. It has been used in the treatment of tuberculosis caused by rifampinsusceptible strains.
• Clinical Use: Tuberculosis (in combination with other antituberculosis drugs)

Technology Process of Rifapentine

There total 2 articles about Rifapentine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-(4-cyclopentylpiperazinyliminomethyl)rifamycin SV (61379-65-5)

Guidance literature:

Reference yield:

→ C47H64N4O12 (61379-65-5)

Guidance literature:

3-Formylrifamycin-SV / 1-Amino4-cyclopentylpiperazin;