Rifapentine

Base Information

Chemical Name:Rifapentine
CAS No.:61379-65-5
Molecular Formula:C47H64N4O12
Molecular Weight:877.045
Hs Code.:3003.20

Synonyms:Antibiotic DL 473IT;Cyclopentylrifampicin;DL 473;KTC 1;MDL 473;Prifitin;Priftin;R 77-3;Rifamycin AF/ACPP;

Suppliers and Price of Rifapentine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Rifapentine
5mg
$ 418.00

TRC
Rifapentine
25mg
$ 85.00

TRC
Rifapentine
50mg
$ 130.00

TCI Chemical
Rifapentine
100MG
$ 216.00

TCI Chemical
Rifapentine
500MG
$ 648.00

Sigma-Aldrich
Rifapentine ≥93%
25mg
$ 320.00

Sigma-Aldrich
Rifapentine ≥93%
100mg
$ 1070.00

Medical Isotopes, Inc.
Rifapentine
50 mg
$ 1960.00

Medical Isotopes, Inc.
Rifapentine
10 mg
$ 870.00

DC Chemicals
Rifapentine(Priftin) >99%
1 g
$ 1000.00

Total 121 raw suppliers

Chemical Property of Rifapentine

Chemical Property:

Appearance/Colour:Crystalline solid
Melting Point:179-180 °C
Refractive Index:1.63
Boiling Point:969.3±65.0 °C(Predicted)
PKA:4.81±0.70(Predicted)
PSA：216.66000
Density:1.337 g/cm³
LogP:5.33450
Storage Temp.:-20°C Freezer
Solubility.:methanol: soluble2mg/mL, clear, red to red-brown

Purity/Quality:

99% ^*data from raw suppliers

Rifapentine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description Rifapentine is a broad spectrum antibiotic highly active against Gram-positive bacteria and Neisseria gonorrhoea. It is reported to be 10 times more active than the structurally related rifampicin against Mycobacrerim fuberculosis. Unlike rifampicin the bioavailability of rifapentine is significantly increased when administered after a meal.
Uses antibacterial (tuberculostatic);'inhibits DNA-dependent RNA polymerase in susceptible strains of Mycobacterium tuberculosis PDE5 inhibitor for erectile dysfunction A semisynthetic ansamycin antibiotic, cyclopentyl derivative of Rifamycin. Treatment of pulmonary tuberculosis Semi-synthetic rifamycin. Antibacterial (tuberculostatic)
Indications Rifapentine is an analogue of rifampin that is active against M. tuberculosis and M. avium. Rifapentine’s mechanism of action, cross-resistance, hepatic induction of P450 enzymes, drug interactions, and toxic profile are similar to those of rifampin. It has been used in the treatment of tuberculosis caused by rifampinsusceptible strains.
Clinical Use Tuberculosis (in combination with other antituberculosis drugs)

Technology Process of Rifapentine

There total 2 articles about Rifapentine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: