4-Hydroxyclonidine

Base Information

Chemical Name:4-Hydroxyclonidine
CAS No.:57101-48-1
Molecular Formula:C₉H₉Cl₂N₃O
Molecular Weight:246.096
Hs Code.:
UNII:EQF32CAD7U
DSSTox Substance ID:DTXSID50205720
Nikkaji Number:J1.578.483K
Wikidata:Q83079358
ChEMBL ID:CHEMBL3277535
Mol file:57101-48-1.mol

Synonyms:4-hydroxyclonidine;4-hydroxyclonidine hydrobromide;4-hydroxyclonidine hydrochloride;para-hydroxyclonidine

Suppliers and Price of 4-Hydroxyclonidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-HYDROXY CLONIDINE 95.00%
10MG
$ 2194.50

American Custom Chemicals Corporation
4-HYDROXY CLONIDINE 95.00%
1MG
$ 779.63

Total 13 raw suppliers

Chemical Property of 4-Hydroxyclonidine

Chemical Property:

Vapor Pressure:4.09E-06mmHg at 25°C
Refractive Index:1.699
Boiling Point:373.706 °C at 760 mmHg
Flash Point:179.811 °C
PSA：56.65000
Density:1.635 g/cm³
LogP:1.90750
XLogP3:1.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:245.0122673
Heavy Atom Count:15
Complexity:250

Purity/Quality:

99% ^*data from raw suppliers

4-HYDROXY CLONIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN=C(N1)NC2=C(C=C(C=C2Cl)O)Cl
Uses A metabolite of Clonidine.

Technology Process of 4-Hydroxyclonidine

There total 1 articles about 4-Hydroxyclonidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109988-69-4
2-<<4-(acetyloxy)-2,6-dichlorophenyl>imino>-1,3-diacetylimidazolidine

: 57101-48-1
p-hydroxyclonidine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)85312-5

Reference yield: 63.0%

: 108-24-7
acetic anhydride

: 57101-48-1
p-hydroxyclonidine

: 109988-69-4
2-<<4-(acetyloxy)-2,6-dichlorophenyl>imino>-1,3-diacetylimidazolidine

Guidance literature:: Heating;
DOI:10.1021/jm00115a008

Reference yield:

: 57101-48-1
p-hydroxyclonidine

: 120215-59-0
2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / Heating

2: 79 percent / NaBH₄, LiCl / bis-(2-methoxy-ethyl) ether / 18 h / 50 °C

3: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 24 h

4: ethanol / 24 h

With sodium tetrahydroborate; sodium hydride; lithium chloride; In ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00115a008