tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

Base Information

• Chemical Name: tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate
• CAS No.: 1211586-14-9
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.319
• Mol file: 1211586-14-9.mol

Synonyms:tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate;1-N-Boc-octahydro-pyrrolo[3,2-b]pyridine

Chemical Property of tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

Chemical Property:

• PSA: 41.57000
• LogP: 2.01450
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

1-N-Boc-octahydro-pyrrolo[3,2-b]pyridine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate

There total 3 articles about tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester (1018950-15-6) → tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate (1211586-14-9)

Guidance literature:

With platinum(IV) oxide; hydrogen; acetic acid; at 50 ℃; for 24h; under 30003 Torr;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate (1211586-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 20 °C

2: hydrogen; acetic acid; platinum(IV) oxide / 24 h / 50 °C / 30003 Torr

With dmap; platinum(IV) oxide; hydrogen; acetic acid; triethylamine; In dichloromethane;

Reference yield:

1H-pyrrolo[3,2-b]pyridine (272-49-1) → tert-butyl octahydro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate (1211586-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 20 °C

2: hydrogen; acetic acid; platinum(IV) oxide / 24 h / 50 °C / 30003 Torr

With dmap; platinum(IV) oxide; hydrogen; acetic acid; triethylamine; In dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

1H-pyrrolo[3,2-b]pyridine

1H-pyrrolo[3,2-b]pyridine-1-carboxylic acid 1,1-dimethylethyl ester

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