6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid

Base Information

• Chemical Name: 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid
• CAS No.: 912770-34-4
• Molecular Formula: C₁₂H₇ClN₂O₂S
• Molecular Weight: 278.719
• Hs Code.: 2934100090
• Mol file: 912770-34-4.mol

Synonyms:6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid;Albb-006788

Chemical Property of 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid

Chemical Property:

• PSA: 82.84000
• Density: 1.6g/cm³
• LogP: 3.41440

Purity/Quality:

98%min ^*data from raw suppliers

6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid

There total 1 articles about 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 6-(4-chlorophenyl)imidazo [2,1-b]thiazole-3-carboxylate (752244-20-5) → C12H7ClN2O2S (912770-34-4)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2016.09.060

Reference yield:

C12H7ClN2O2S (912770-34-4) → 6-(4-chlorophenyl)-N-((1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)imidazo [2,1-b]thiazole-3-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 8.17 h / 0 - 20 °C / Cooling with ice

2: sodium L-ascorbate / water; tert-butyl alcohol / 5 h / 20 °C

With benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2016.09.060

Reference yield:

C12H7ClN2O2S (912770-34-4) → 6-(4-chlorophenyl)-N-((1-(3,4,5-trimethoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)imidazo [2,1-b]thiazole-3-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 8.17 h / 0 - 20 °C / Cooling with ice

2: sodium L-ascorbate / water; tert-butyl alcohol / 5 h / 20 °C

With benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2016.09.060

upstream raw materials:

ethyl 6-(4-chlorophenyl)imidazo [2,1-b]thiazole-3-carboxylate

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