5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole

Base Information

Chemical Name:5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole
CAS No.:69439-09-4
Molecular Formula:C₆H₆F₃NOS
Molecular Weight:197.181
Hs Code.:
ChEMBL ID:CHEMBL3228123
DSSTox Substance ID:DTXSID30500962
Mol file:69439-09-4.mol

Synonyms:69439-09-4;5-(2-HYDROXYETHYL)-4-(TRIFLUOROMETHYL)THIAZOLE;2-[4-(Trifluoromethyl)thiazol-5-yl]ethanol;2-[4-(trifluoromethyl)-1,3-thiazol-5-yl]ethanol;2-(4-(Trifluoromethyl)thiazol-5-yl)ethanol;CHEMBL3228123;DTXSID30500962;MFCD08447567;AKOS006291151;FT-0641238;5-(2-hydroxyethyl)-4-trifluoromethyl-1,3-thiazole;2-[4-(trifluoromethyl)-1,3-thiazol-5-yl]ethan-1-ol

Suppliers and Price of 5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-(2-HYDROXYETHYL)-4-(TRIFLUOROMETHYL)THIAZOLE 95.00%
1G
$ 1492.05

AHH
5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole 98%
1g
$ 688.00

Total 6 raw suppliers

Chemical Property of 5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole

Chemical Property:

Vapor Pressure:0.03mmHg at 25°C
Boiling Point:234°C at 760 mmHg
PKA:14.33±0.10(Predicted)
Flash Point:95.3°C
PSA：61.36000
Density:1.45g/cm³
LogP:1.69670
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:197.01221947
Heavy Atom Count:12
Complexity:152

Purity/Quality:

99% ^*data from raw suppliers

5-(2-HYDROXYETHYL)-4-(TRIFLUOROMETHYL)THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC(=C(S1)CCO)C(F)(F)F

Technology Process of 5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole

There total 3 articles about 5-(2-Hydroxyethyl)-4-(trifluoromethyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69243-11-4
5-(2-methoxy-ethyl)-4-trifluoromethyl-thiazole

: 69439-09-4
2-(4-trifluoromethyl-thiazol-5-yl)-ethanol

Guidance literature:: With boron tribromide; In dichloromethane;
DOI:10.1021/jm00189a017

Reference yield:

: 69243-10-3
1,1,1-trifluoro-5-methoxy-pentan-2-one

: 69439-09-4
2-(4-trifluoromethyl-thiazol-5-yl)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: (i) Br₂, CCl₄, (ii) /BRN= 1732552/, Et₂O

2: BBr₃ / CH₂Cl₂

With boron tribromide; In dichloromethane;
DOI:10.1021/jm00189a017

Reference yield:

: 69243-08-9
4,4,4-trifluoro-2-(2-methoxy-ethyl)-3-oxo-butyric acid ethyl ester

: 69439-09-4
2-(4-trifluoromethyl-thiazol-5-yl)-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl, aq. AcOH

2: (i) Br₂, CCl₄, (ii) /BRN= 1732552/, Et₂O

3: BBr₃ / CH₂Cl₂

With hydrogenchloride; boron tribromide; acetic acid; In dichloromethane;
DOI:10.1021/jm00189a017