Technology Process of (8-(methyldithio)-1-naphthyl)methyl-8-amino-2,6-anhydro-3,8-dideoxyoctonate
There total 9 articles about (8-(methyldithio)-1-naphthyl)methyl-8-amino-2,6-anhydro-3,8-dideoxyoctonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
tetrahydrofuran;
for 72h;
Ambient temperature;
DOI:10.1021/jm00123a021
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / Dowex HCR-S (H(1+)) resin / 4 h / Ambient temperature
2: 100 percent / H2 / 5 percent Pd/C / 3 h / Ambient temperature
3: 90 percent / Et3N / methanol / 1 h / Ambient temperature
4: 82 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / Ambient temperature
5: 1) 0.5 N aq. LiOH / 1) MeOH, RT, 1 h
6: 79 percent / N,N-bis(2-oxo-3-oxazolidinyl)phosphordiamidic chloride / tetrahydrofuran / 24 h / Ambient temperature
7: 40 percent / 2 N aq. trifluoroacetic acid / tetrahydrofuran / 72 h / Ambient temperature
With
lithium hydroxide; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; Dowex HCR-S (H(1+)) resin; hydrogen; pyridinium p-toluenesulfonate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00123a021
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / H2 / 5 percent Pd/C / 3 h / Ambient temperature
2: 90 percent / Et3N / methanol / 1 h / Ambient temperature
3: 82 percent / pyridinium p-toluenesulfonate / CH2Cl2 / 3 h / Ambient temperature
4: 1) 0.5 N aq. LiOH / 1) MeOH, RT, 1 h
5: 79 percent / N,N-bis(2-oxo-3-oxazolidinyl)phosphordiamidic chloride / tetrahydrofuran / 24 h / Ambient temperature
6: 40 percent / 2 N aq. trifluoroacetic acid / tetrahydrofuran / 72 h / Ambient temperature
With
lithium hydroxide; N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride; hydrogen; pyridinium p-toluenesulfonate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00123a021
![(3aR,4R,6S,7aR)-4-[(R)-2-tert-Butoxycarbonylamino-1-(tetrahydro-pyran-2-yloxy)-ethyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carboxylic acid 8-methyldisulfanyl-naphthalen-1-ylmethyl ester](/Databaselist/images/loading.webp)
