1-(6-Bromopyridin-2-yl)piperazine

Base Information

Chemical Name:1-(6-Bromopyridin-2-yl)piperazine
CAS No.:219635-91-3
Molecular Formula:C9H12BrN3
Molecular Weight:242.118
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90587931
Wikidata:Q82480403
Mol file:219635-91-3.mol

Synonyms:1-(6-bromopyridin-2-yl)piperazine;219635-91-3;CHEMBRDG-BB 4012280;SCHEMBL1433085;DTXSID90587931;GS0791;STK690276;AKOS006337423;AB48370;DA-08076;CS-0436720;F84109;2-bromo-6-(piperazin-1-yl)pyridine, AldrichCPR;EN300-1913830;J-503452

Suppliers and Price of 1-(6-Bromopyridin-2-yl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(6-Bromopyridin-2-yl)piperazine 95+%
1g
$ 510.00

Chemenu
1-(6-bromopyridin-2-yl)piperazine 95%
1g
$ 482.00

American Custom Chemicals Corporation
1-(6-BROMOPYRIDIN-2-YL)PIPERAZINE 95.00%
5MG
$ 504.03

Alichem
1-(6-Bromopyridin-2-yl)piperazine
1g
$ 411.84

Total 12 raw suppliers

Chemical Property of 1-(6-Bromopyridin-2-yl)piperazine

Chemical Property:

Vapor Pressure:4.16E-06mmHg at 25°C
Boiling Point:384.2°C at 760 mmHg
PKA:8.48±0.10(Predicted)
Flash Point:186.2°C
PSA：28.16000
Density:1.448g/cm³
LogP:1.64750
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:241.02146
Heavy Atom Count:13
Complexity:159

Purity/Quality:

98%min ^*data from raw suppliers

1-(6-Bromopyridin-2-yl)piperazine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1)C2=NC(=CC=C2)Br

Technology Process of 1-(6-Bromopyridin-2-yl)piperazine

There total 5 articles about 1-(6-Bromopyridin-2-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(6-bromopyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 219635-91-3
1-(6-bromopyridin-2-yl)piperazine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm701375u

Reference yield:

: 854159-21-0
1-(6-bromo-2-pyridyl)-4-tritylpiperazine

: 219635-91-3
1-(6-bromopyridin-2-yl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2005.03.026

Reference yield:

: 854159-11-8
1-(2-pyridyl)-4-tritylpiperazine

: 219635-91-3
1-(6-bromopyridin-2-yl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; 2-(dimethylamino)ethanol / toluene; hexane / 2.5 h / 20 °C

1.2: 95 percent / CBr₄ / toluene; hexane; tetrahydrofuran / -78 - 0 °C

2.1: 60 mg / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

With n-butyllithium; 2-(N,N-dimethylamino)ethanol; trifluoroacetic acid; In hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2005.03.026