4-chloro-2-(2-pyridinylmethyl)benzenamine

Base Information

• Chemical Name: 4-chloro-2-(2-pyridinylmethyl)benzenamine
• CAS No.: 115177-69-0
• Molecular Formula: C₁₂H₁₁ClN₂
• Molecular Weight: 218.686
• Mol file: 115177-69-0.mol

Synonyms:4-chloro-2-(2-pyridinylmethyl)benzenamine

Chemical Property of 4-chloro-2-(2-pyridinylmethyl)benzenamine

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-2-(2-pyridinylmethyl)benzenamine

There total 8 articles about 4-chloro-2-(2-pyridinylmethyl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(o-azidobenzyl)pyridine (115177-61-2) → 2-(2-amino-5-chlorobenzyl)pyridine (115177-69-0)

Guidance literature:

With aluminium trichloride; In dichloromethane;

Reference yield:

2-(5-chloro-2-nitrobenzyl)pyridine (733008-44-1) → 2-(2-amino-5-chlorobenzyl)pyridine (115177-69-0)

Guidance literature:

2-(5-chloro-2-nitrobenzyl)pyridine; With hydrogenchloride; tin; In ethanol; at 20 ℃; for 2h;

With sodium hydroxide; In ethanol; water; at 0 ℃; Neutralization;

Reference yield:

2-bromo-pyridine (109-04-6) → 2-(2-amino-5-chlorobenzyl)pyridine (115177-69-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) butyl-lithium / 1.) ether, -70 deg C, 10 min, 2.) ether, -70 deg C, 30 min, RT, 2 h

2: 87 percent / H₂ / 10percent Pd-C / aq. ethanol

3: 1.) hydroiodic acid, 2.) sodium metabisulphite, 50percent sodium hydroxide / 1.) reflux, 5 h, 2.) H₂O, 100 deg C, 5 min

4: 1.) conc.HCl, sodium nitrite, 2.) sodium azide, sodium acetate / 1.) water, dioxane, 0 deg C, 2.) water, 0 deg C - 5 deg C, RT, 30 min

5: 63 percent / aluminium chloride / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; sodium disulfite; n-butyllithium; aluminium trichloride; sodium azide; hydrogen iodide; hydrogen; sodium acetate; sodium nitrite; palladium on activated charcoal; In ethanol; dichloromethane;

upstream raw materials:

2-(o-azidobenzyl)pyridine

2-bromo-pyridine

2-(2-aminobenzyl)pyridine

(2-aminophenyl)(pyridin-2-yl)methanol

Downstream raw materials:

N-[4-Chloro-2-(pyridin-2-ylmethyl)-phenyl]-3,4-dimethoxybenzenesulfonamide