5-Methyl-2-(4-morpholinyl)aniline

Base Information

• Chemical Name: 5-Methyl-2-(4-morpholinyl)aniline
• CAS No.: 91429-92-4
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.261
• Hs Code.: 2934999090
• Mol file: 91429-92-4.mol

Synonyms:5-Methyl-2-(4-morpholinyl)aniline;(5-methyl-2-morpholin-4-ylphenyl)amine;(5-methyl-2-morpholino-phenyl)amine;5-methyl-2-morpholin-4-ylaniline;5-methyl-2-morpholin-4-yl-aniline;5-methyl-2-morpholinoaniline;5-methyl-2-morpholino-aniline

Chemical Property of 5-Methyl-2-(4-morpholinyl)aniline

Chemical Property:

• PSA: 38.49000
• LogP: 2.06000

Purity/Quality:

98%min ^*data from raw suppliers

(5-methyl-2-morpholin-4-ylphenyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methyl-2-(4-morpholinyl)aniline

There total 3 articles about 5-Methyl-2-(4-morpholinyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(morpholin-4-yl)-5-methylnitrobenzene (91181-62-3) → 2-(morpholin-4-yl)-5-methylaniline (91429-92-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.7b00468

Reference yield:

1-chloro-4-methyl-2-nitro-benzene (89-60-1) → 2-(morpholin-4-yl)-5-methylaniline (91429-92-4)

Guidance literature:

Multi-step reaction with 2 steps

2: Fe, aq. NH₄Cl

With iron; ammonium chloride;

DOI:10.1021/ja01477a038

Reference yield:

4-fluoro-3-nitrotoluene (446-11-7) → 2-(morpholin-4-yl)-5-methylaniline (91429-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 12 h / 122 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dimethyl sulfoxide;

DOI:10.1021/acs.jmedchem.7b00468

upstream raw materials:

2-(morpholin-4-yl)-5-methylnitrobenzene

1-chloro-4-methyl-2-nitro-benzene

4-fluoro-3-nitrotoluene

Downstream raw materials:

1-[(2-chloro-4-fluorophenyl)methyl]-4-[5-methyl-2-(4-morpholinyl)phenyl]-2,3-piperazinedione

5-methyl-2-morpholinophenyl isothiocyanate

N-(5-methyl-2-morpholinophenyl)acetamidine

Refernces

• 1、 -. "DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS". Page/Page column 82. . Retrieved 2010/11/17.