Lorglumide

Base Information

Chemical Name:Lorglumide
CAS No.:97964-56-2
Molecular Formula:C₂₂H₃₂Cl₂N₂O₄
Molecular Weight:459.413
Hs Code.:
UNII:LAD1UQ73BE
DSSTox Substance ID:DTXSID2046961
Wikipedia:Lorglumide
Wikidata:Q12745785
NCI Thesaurus Code:C81601
Pharos Ligand ID:8BA5AUMQTTJK
ChEMBL ID:CHEMBL24938
Mol file:97964-56-2.mol

Synonyms:4-((3,4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxopentanoic acid;CR 1409;CR-1409;lorglumide

Suppliers and Price of Lorglumide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Lorglumide
50mg
$ 250.00

TRC
Lorglumide
250mg
$ 970.00

Alfa Aesar
Lorglumide sodium salt, 98+%
100mg
$ 616.00

Alfa Aesar
Lorglumide sodium salt, 98+%
25mg
$ 190.00

Total 5 raw suppliers

Chemical Property of Lorglumide

Chemical Property:

Vapor Pressure:2.65E-16mmHg at 25°C
Boiling Point:621.4°Cat760mmHg
PKA:4.47±0.10(Predicted)
Flash Point:329.6°C
PSA：86.71000
Density:1.195g/cm³
LogP:5.55650
Solubility.:45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg
XLogP3:5.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:14
Exact Mass:458.1739129
Heavy Atom Count:30
Complexity:537

Purity/Quality:

97% ^*data from raw suppliers

Lorglumide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
Uses Lorglumide is a specific cholecytokinin receptor antagonist. It is also an intermediate in synthesizing Lorglumide Sodium Salt (L469910), a nonpeptidic antagonist of the CCK A receptor, and minimally effective at the CCK B receptor. It blocks CCK -mediated muscle contraction, pancreatic growth and secretion.

Technology Process of Lorglumide

There total 4 articles about Lorglumide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.7%

: 104252-86-0
3,4-Dichloro-N-(2,6-dioxo-tetrahydro-pyran-3-yl)-benzamide

: 2050-92-2
Di-n-amylamine

: 118919-27-0,118919-28-1,97964-56-2
lorglumide

: 102743-06-6
2-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-butyric acid

Guidance literature:: In water; at 5 - 10 ℃; for 3h;

Reference yield:

: 617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
Glutamic acid

: 118919-27-0,118919-28-1,97964-56-2
lorglumide

Guidance literature:: Multi-step reaction with 3 steps

1: 76.4 percent / 1N NaOH / H₂O / 4 h / 15 - 20 °C

2: 89.3 percent / acetic anhydride / diisopropyl ether / 2 h / 70 °C

3: tetrahydrofuran / 3 h / 25 °C

With sodium hydroxide; acetic anhydride; In tetrahydrofuran; di-isopropyl ether; water;

Reference yield:

: 104252-58-6
2-(3,4-Dichloro-benzoylamino)-pentanedioic acid

: 118919-27-0,118919-28-1,97964-56-2
lorglumide

Guidance literature:: Multi-step reaction with 2 steps

1: 89.3 percent / acetic anhydride / diisopropyl ether / 2 h / 70 °C

2: tetrahydrofuran / 3 h / 25 °C

With acetic anhydride; In tetrahydrofuran; di-isopropyl ether;