2-ThiazoleMethanaMine, α-(phenylMethyl)-, (αS)-

Base Information

• Chemical Name: 2-ThiazoleMethanaMine, α-(phenylMethyl)-, (αS)-
• CAS No.: 130199-65-4
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.296
• Mol file: 130199-65-4.mol

Synonyms:2-ThiazoleMethanaMine, α-(phenylMethyl)-, (αS)-;(S)-2-phenyl-1-(thiazol-2-yl)ethanaMine;(S)-2-phenyl-1-(thiazol-2-yl)ethan-1-amine;(S)-2-phenyl-1-(thiazol-2-yl)ethanaminedihydrochloride

Chemical Property of 2-ThiazoleMethanaMine, α-(phenylMethyl)-, (αS)-

Chemical Property:

• PSA: 67.15000
• LogP: 3.08590

Purity/Quality:

97% ^*data from raw suppliers

2-Thiazolemethanamine,α-(phenylmethyl)-,(αS)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ThiazoleMethanaMine, α-(phenylMethyl)-, (αS)-

There total 20 articles about 2-ThiazoleMethanaMine, α-(phenylMethyl)-, (αS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2R,3R)-3-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-3-hydroxy-2-methylpropanoic acid (133565-38-5) → (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine (130199-65-4)

Guidance literature:

With hydrogen bromide; In acetic acid; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)92123-3

Reference yield: 99.0%

(S)-benzyl 2-phenyl-1-(thiazol-2-yl)ethylcarbamate (133565-36-3) → (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine (130199-65-4)

Guidance literature:

With hydrogen bromide; acetic acid; for 4h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80547-0

Reference yield: 95.0%

tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate (120205-51-8) → (1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethan-1-amine (130199-65-4)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80547-0

upstream raw materials:

tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate

(2R,3R)-3-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-3-hydroxy-2-methylpropanoic acid

(S)-benzyl 2-phenyl-1-(thiazol-2-yl)ethylcarbamate

2-[(1S)-1-azido-2-phenylethyl]-1,3-thiazole

Downstream raw materials:

tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate

Boc-(2S,3R,4S)-norDap-(S)-Doe