2-AMino-5-iodo-nicotinic acid Methyl ester

Base Information

• Chemical Name: 2-AMino-5-iodo-nicotinic acid Methyl ester
• CAS No.: 1227048-78-3
• Molecular Formula: C7H7IN2O2
• Molecular Weight: 278.049
• Mol file: 1227048-78-3.mol

Synonyms:2-AMino-5-iodo-nicotinic acid Methyl ester;Methyl 2-aMino-5-iodonicotinate

Chemical Property of 2-AMino-5-iodo-nicotinic acid Methyl ester

Chemical Property:

• PSA: 65.21000
• LogP: 1.63620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl2-Amino-5-iodonicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-5-iodo-nicotinic acid Methyl ester

There total 1 articles about 2-AMino-5-iodo-nicotinic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-aminonicotinate (14667-47-1) → 2-amino-5-iodonicotinic acid methyl ester (1227048-78-3)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; for 16h;

Reference yield:

4-Fluorophenol (371-41-5) + 2-amino-5-iodonicotinic acid methyl ester (1227048-78-3) → 2-amino-5-(4-fluorophenoxy)nicotinic acid methyl ester (1336910-84-9)

Guidance literature:

4-Fluorophenol; With caesium carbonate; In 1,4-dioxane; at 50 ℃; for 0.333333h;

2-amino-5-iodonicotinic acid methyl ester; copper(l) iodide; In 1,4-dioxane; for 16h; Reflux;

Reference yield:

2-amino-5-iodonicotinic acid methyl ester (1227048-78-3) → 2-amino-5-(4-fluorophenoxy)nicotinic acid (1336910-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: caesium carbonate / 1,4-dioxane / 0.33 h / 50 °C

1.2: 16 h / Reflux

2.1: water; lithium hydroxide / methanol / 6 h

With water; caesium carbonate; lithium hydroxide; In 1,4-dioxane; methanol;

upstream raw materials:

methyl 2-aminonicotinate

Downstream raw materials:

2-amino-5-(4-fluorophenoxy)nicotinic acid methyl ester

2-amino-5-(4-fluorophenoxy)nicotinic acid

Refernces