Technology Process of Acetamide, N-[hexahydro-1-indanyl]- (3CI)
There total 5 articles about Acetamide, N-[hexahydro-1-indanyl]- (3CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; 1,2-bis((2S,5S)-2,5-dimethylphospholano)ethane;
In
isopropyl alcohol;
at 20 ℃;
for 24h;
under 7500.75 Torr;
Overall yield = 96 percent; Optical yield = 32 percent de; enantioselective reaction;
DOI:10.1021/jacs.1c09975
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; sodium acetate / methanol / 60 °C / Inert atmosphere
2: acetic acid; iron / toluene / 70 °C / Inert atmosphere
3: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)ethane; hydrogen / isopropyl alcohol / 24 h / 20 °C / 7500.75 Torr
With
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydroxylamine hydrochloride; hydrogen; sodium acetate; iron; 1,2-bis((2S,5S)-2,5-dimethylphospholano)ethane; acetic acid;
In
methanol; isopropyl alcohol; toluene;
DOI:10.1021/jacs.1c09975
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid; iron / toluene / 70 °C / Inert atmosphere
2: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 1,2-bis((2S,5S)-2,5-dimethylphospholano)ethane; hydrogen / isopropyl alcohol / 24 h / 20 °C / 7500.75 Torr
With
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; iron; 1,2-bis((2S,5S)-2,5-dimethylphospholano)ethane; acetic acid;
In
isopropyl alcohol; toluene;
DOI:10.1021/jacs.1c09975