F-AMidine

Base Information

Chemical Name:F-AMidine
CAS No.:877617-45-3
Molecular Formula:C₁₄H₁₉FN₄O₂
Molecular Weight:294.329
Hs Code.:
Mol file:877617-45-3.mol

Synonyms:F-AMidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide

Suppliers and Price of F-AMidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
F-Amidine
2.5mg
$ 185.00

Total 2 raw suppliers

Chemical Property of F-AMidine

Chemical Property:

PSA：112.55000
LogP:2.80200

Purity/Quality:

99% ^*data from raw suppliers

F-Amidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

Technology Process of F-AMidine

There total 6 articles about F-AMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404060-34-9
C₁₂H₁₇N₃O₂

: 3862-78-0
ethyl 2-fluoroacetimidate hydrochloride

: 1404060-13-4,877617-45-3
C₁₄H₁₉FN₄O₂

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 2h;
DOI:10.1021/ml300288d

Reference yield:

: 1404060-28-1
N¹-benzoyl-N⁴-Boc-D-ornithine acid

: 1404060-13-4,877617-45-3
C₁₄H₁₉FN₄O₂

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / dichloromethane / 0.17 h / Cooling with ice

2: ammonium hydroxide / dichloromethane / 16.17 h / 20 °C / Cooling with ice

3: trifluoroacetic acid / neat (no solvent) / 1 h / 20 °C

4: triethylamine / methanol / 2 h / 20 °C

With 4-methyl-morpholine; ammonium hydroxide; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/ml300288d

Reference yield:

: 184576-63-4
(R)-2-amino-5-(tert-butoxycarbonylamino)pentanoic acid

: 1404060-13-4,877617-45-3
C₁₄H₁₉FN₄O₂

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / diethyl ether / 18.17 h / 23 °C / Cooling with ice

2: 4-methyl-morpholine / dichloromethane / 0.17 h / Cooling with ice

3: ammonium hydroxide / dichloromethane / 16.17 h / 20 °C / Cooling with ice

4: trifluoroacetic acid / neat (no solvent) / 1 h / 20 °C

5: triethylamine / methanol / 2 h / 20 °C

With 4-methyl-morpholine; ammonium hydroxide; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ml300288d