Bizelesin

Base Information

Chemical Name:Bizelesin
CAS No.:129655-21-6
Molecular Formula:C₄₃H₃₆Cl₂N₈O₅
Molecular Weight:815.715
Hs Code.:
Mol file:129655-21-6.mol

Synonyms:Benzo[1,2-b:4,3-b']dipyrrol-4-ol,6,6'-[carbonylbis(imino-1H-indole-5,2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(8S,8'S)- (9CI); Benzo[1,2-b:4,3-b']dipyrrol-4-ol,6,6'-[carbonylbis(imino-1H-indole-5,2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,[S-(R*,R*)]-; Bizelesin; NSC 615291; U 77779

Suppliers and Price of Bizelesin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bizelesin
100mg
$ 35750.00

Total 12 raw suppliers

Chemical Property of Bizelesin

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：185.37000
Density:1.604g/cm³
LogP:9.52540

Purity/Quality:

99%, ^*data from raw suppliers

Bizelesin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both si ngle-strand lesions and double-strand DNA cross-links. liferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).

Technology Process of Bizelesin

There total 9 articles about Bizelesin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110314-54-0
(S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrole hydrochloride

: 129655-37-4
5,5'-(carbonyldiimino)bis-1H-indole-2-carboxylic acid

: 129655-21-6
bizelesin

Guidance literature:: With 2,4-dichlorophenoxyacetic acid dimethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; at 25 ℃; for 2h;
DOI:10.1021/ja00023a085

Reference yield:

: 71086-99-2
ethyl 5-amino-1H-indole-2-carboxylate

: 129655-21-6
bizelesin

Guidance literature:: Multi-step reaction with 3 steps

1: (i-Pr)2NEt, DMAP / tetrahydrofuran / 16 h / -98 - 0 °C

2: aq. NaOH, pyridine / 103 h / 25 - 55 °C

3: EDC, DMA / 2 h / 25 °C

With pyridine; dmap; sodium hydroxide; 2,4-dichlorophenoxyacetic acid dimethylamine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ja00023a085

Reference yield:

: 112836-67-6
(S)-1,6-dihydro-1-(hydroxymethyl)-8-methyl-5-(phenylmethoxy)-benzo[1,2-b:4,3-b']dipyrrole-3(2H)-carboxylic acid 1,1-dimethylethyl ester

: 129655-21-6
bizelesin

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / PPh₃, CCl₄ / CH₂Cl₂ / 7 h / Ambient temperature

2: 88 percent / 25percent HCO₂NH₄ / 10percentPd-C / tetrahydrofuran / 6 h / 0 °C

3: 3M HCl / ethyl acetate / 1 h / Ambient temperature

4: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With hydrogenchloride; tetrachloromethane; ammonium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; 10% palladium on active carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.3987/COM-97-7920