2-Hydroxy-4-phenylbenzoic acid

Base Information

Chemical Name:2-Hydroxy-4-phenylbenzoic acid
CAS No.:4482-27-3
Molecular Formula:C13H10O3
Molecular Weight:214.2167
Hs Code.:2922299090
ChEMBL ID:CHEMBL475848
DSSTox Substance ID:DTXSID50483389
Wikidata:Q82320674
Mol file:4482-27-3.mol

Synonyms:4482-27-3;2-HYDROXY-4-PHENYLBENZOIC ACID;3-Hydroxy-[1,1'-biphenyl]-4-carboxylic acid;CHEMBL475848;2-oxidanyl-4-phenyl-benzoic acid;4-phenylsalicylic acid;3-Hydroxy-[1,1'-biphenyl]-4-carboxylicacid;[1,1'-Biphenyl]-4-carboxylic acid, 3-hydroxy-;SCHEMBL2536183;DTXSID50483389;BDBM50565954;MFCD14702018;AKOS015888634;BS-28780;CS-0208806;A904683

Suppliers and Price of 2-Hydroxy-4-phenylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Hydroxy-4-phenylbenzoicAcid
500mg
$ 205.00

Crysdot
3-Hydroxy-[1,1'-biphenyl]-4-carboxylicacid 95+%
1g
$ 330.00

American Custom Chemicals Corporation
3-HYDROXY-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 95.00%
5MG
$ 500.58

Alichem
3-Hydroxybiphenyl-4-carboxylicacid
250mg
$ 489.60

Alichem
3-Hydroxybiphenyl-4-carboxylicacid
1g
$ 1445.30

Alichem
3-Hydroxybiphenyl-4-carboxylicacid
500mg
$ 831.30

AK Scientific
3-Hydroxy-[1,1'-biphenyl]-4-carboxylicacid
1g
$ 517.00

Total 8 raw suppliers

Chemical Property of 2-Hydroxy-4-phenylbenzoic acid

Chemical Property:

Melting Point:207-208 °C
Boiling Point:414.1±45.0 °C(Predicted)
PKA:2.97±0.10(Predicted)
PSA：57.53000
Density:1.292±0.06 g/cm3(Predicted)
LogP:2.75740
Storage Temp.:2-8°C
Solubility.:DMSO (Slightly), Methanol (Very Slightly, Sonicated)
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:214.062994177
Heavy Atom Count:16
Complexity:246

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-4-phenylbenzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)O)O
Uses 2-Hydroxy-4-phenylbenzoic Acid (CAS# 4482-27-3) is a useful building block used in the synthesis of chromones for use as tyrosine phosphatase inhibitors. Being a salicylic acid, 2-hydroxy-4-phenylbenzoic acid has been proposed for use as an anti-inflammatory drug.

Technology Process of 2-Hydroxy-4-phenylbenzoic acid

There total 7 articles about 2-Hydroxy-4-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1666-28-0
4-bromosalicylic acid

: 98-80-6
phenylboronic acid

: 4482-27-3
3-hydroxy-[1,1'-biphenyl]-4-carboxylic acid

Guidance literature:: With PdCl₂(NH₂CH₂COOH)₂; potassium carbonate; In water; at 35 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c01762

Reference yield: 56.0%

: 175152-70-2
methyl 3-methoxy-[1,1‘-biphenyl]-4-carboxylate

: 4482-27-3
3-hydroxy-[1,1'-biphenyl]-4-carboxylic acid

Guidance literature:: methyl 3-methoxy-[1,1‘-biphenyl]-4-carboxylate; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 24h;

With water; In dichloromethane; Cooling with ice;
DOI:10.1016/j.bmc.2009.02.060