alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid

Base Information

Chemical Name:alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid
CAS No.:130146-18-8
Molecular Formula:C₉H₁₂N₂O₆
Molecular Weight:244.204
Hs Code.:
DSSTox Substance ID:DTXSID80926613
Nikkaji Number:J360.653H
ChEMBL ID:CHEMBL291274
Mol file:130146-18-8.mol

Synonyms:2-amino-3-(3-(carboxymethoxy)-5-methylisoxazol-4-yl)propionic acid;2-AMOA;alpha-amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid;OMOA

Suppliers and Price of alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(R,S)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionicAcidSesquihydrate
25 mg
$ 1880.00

Medical Isotopes, Inc.
(R,S)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionicAcidSesquihydrate
5 mg
$ 860.00

Total 8 raw suppliers

Chemical Property of alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid

Chemical Property:

Vapor Pressure:6.5E-11mmHg at 25°C
Melting Point:230(dec.)
Boiling Point:502.4°C at 760 mmHg
Flash Point:257.6°C
PSA：299.45000
Density:1.481g/cm³
LogP:0.00930
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:Hot Methanol, Water
XLogP3:-2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:244.06953611
Heavy Atom Count:17
Complexity:297

Purity/Quality:

98% ^*data from raw suppliers

(R,S)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]-propionicAcidSesquihydrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NO1)OCC(=O)O)CC(C(=O)O)N
Uses A selective inhibitor of [3H]-AMPA binding in rat brain membranes. AMOA shows little affinity for [3H]-kainate binding sites or other sites on the NMDA receptor-channel complex, as represented by binding of [3H]-CPP, [3H]-gly or [3H]-MK-801. AMOA

Technology Process of alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid

There total 3 articles about alpha-Amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 130146-22-4
methyl 2-acetamido-2-(methoxycarbonyl)-3-<3-<(ethoxycarbonyl)methoxy>-5-methylisoxazol-4-yl>propionate

: 131417-68-0,130146-18-8
AMOA

Guidance literature:: With hydrogenchloride; for 10h; Heating;
DOI:10.1021/jm00105a019

Reference yield:

: 130146-20-2
2-Acetylamino-2-(3-methoxy-5-methyl-isoxazol-4-ylmethyl)-malonic acid dimethyl ester

: 131417-68-0,130146-18-8
AMOA

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / 33percent hydrogen bromide / acetic acid / 20 h / Ambient temperature

2: 1.) potassium carbonate / 1.) acetone, 50 deg C, 90 min, 2.) 50 deg C, 20 h

3: 40 percent / 2 M hydrochloric acid / 10 h / Heating

With hydrogenchloride; hydrogen bromide; potassium carbonate; In acetic acid;
DOI:10.1021/jm00105a019

Reference yield:

: 130146-21-3
methyl 2-(acetylamino)-2-(methoxycarbonyl)-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionate

: 131417-68-0,130146-18-8
AMOA

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium carbonate / 1.) acetone, 50 deg C, 90 min, 2.) 50 deg C, 20 h

2: 40 percent / 2 M hydrochloric acid / 10 h / Heating

With hydrogenchloride; potassium carbonate;
DOI:10.1021/jm00105a019