2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 954239-49-7
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.213
• Mol file: 954239-49-7.mol

Synonyms:2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER;2,3-Dihydro-2-oxo-1H-indole-6-carboxylic acid ethyl ester;Ethyl 2-oxoindoline-6-carboxylate

Chemical Property of 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 394.5±42.0 °C(Predicted)
• PKA: 13.54±0.20(Predicted)
• PSA: 58.89000
• Density: 1.240
• LogP: 1.44300
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

ethyl2-oxoindoline-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER

There total 2 articles about 2-OXO-2,3-DIHYDRO-1H-INDOLE-6-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-carboxymethyl-3-nitrobenzoic acid ethyl ester (1023942-16-6) → 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester (954239-49-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; at 20 ℃; for 1h; under 2585.81 Torr;

DOI:10.1021/jm900431g

Reference yield:

→ 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester (954239-49-7)

Guidance literature:

Reference yield: 76.0%

2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester (954239-49-7) + acetic anhydride (108-24-7) + triethoxymethylbenzene (1663-61-2) → (E)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester (1168152-00-8)

Guidance literature:

at 110 ℃; for 3.5h;

DOI:10.1021/jm900431g

upstream raw materials:

4-carboxymethyl-3-nitrobenzoic acid ethyl ester

Downstream raw materials:

1-acetyl-3-(1-ethoxy-1-phenylmethylene)-6-ethoxycarbonyl-2-indolinone

2-Oxo-2,3-dihydro-1H-indole-6-carboxylic acid

(E)-1-acetyl-3-(ethoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester