Benzenemethanamine, 2,4-difluoro-5-methyl-

Base Information

• Chemical Name: Benzenemethanamine, 2,4-difluoro-5-methyl-
• CAS No.: 329314-63-8
• Molecular Formula: C₈H₉F₂N
• Molecular Weight: 157.163
• Hs Code.: 2921490090
• DSSTox Substance ID: DTXSID10443323
• Nikkaji Number: J1.463.047C
• Wikidata: Q82261078
• Mol file: 329314-63-8.mol

Synonyms:329314-63-8;(2,4-Difluoro-5-methylphenyl)methanamine;BENZENEMETHANAMINE, 2,4-DIFLUORO-5-METHYL-;2,4-Difluoro-5-methylbenzylamine;1-(2,4-difluoro-5-methylphenyl)methanamine;DTXSID10443323;MFCD18825364;AKOS017413530;JS-5250;2,4-Difluoro-5-methylbenzenemethanamine;2,4-Difluoro-5-methyl-benzenemethanamine

Chemical Property of Benzenemethanamine, 2,4-difluoro-5-methyl-

Chemical Property:

• PSA: 26.02000
• LogP: 2.43220
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 157.07030562
• Heavy Atom Count: 11
• Complexity: 129

Purity/Quality:

99%+ ^*data from raw suppliers

2,4-Difluoro-5-methylbenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1F)F)CN

Technology Process of Benzenemethanamine, 2,4-difluoro-5-methyl-

There total 2 articles about Benzenemethanamine, 2,4-difluoro-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,4-difluoro-5-methylbenzonitrile (329314-68-3) → 2,4-difluoro-5-methylbenzylamine (329314-63-8)

Guidance literature:

With borane-THF; In tetrahydrofuran; Heating;

DOI:10.1039/b007455l

Reference yield:

1-bromo-2,4-difluoro-5-methylbenzene (159277-47-1) → 2,4-difluoro-5-methylbenzylamine (329314-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / dimethylformamide / 3 h / 160 °C

2: 67 percent / BH₃*THF / tetrahydrofuran / Heating

With borane-THF; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

2,4-difluoro-5-methylbenzonitrile

1-bromo-2,4-difluoro-5-methylbenzene