(R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide
• CAS No.: 891782-29-9
• Molecular Formula: C₉H₁₇NOS
• Molecular Weight: 187.306
• Mol file: 891782-29-9.mol

Synonyms:(R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide

Chemical Property of (R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide

Chemical Property:

• PSA: 48.64000
• LogP: 3.32930

Purity/Quality:

99% ^*data from raw suppliers

(R)-N-Cyclopentylidene-2-methylpropane-2-sulfinamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide

There total 3 articles about (R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclopentanone (120-92-3) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-2-methyl-N-(cyclopentylidene)propane-2-sulfinamide (891782-29-9)

Guidance literature:

cyclopentanone; With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

(S)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at 65 ℃; Inert atmosphere;

DOI:10.1002/chem.201702616

Reference yield: 77.0%

cyclopentanone (120-92-3) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R)-N-cyclopentylidene-2-methylpropane-2-sulfinamide (891782-29-9)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; at 50 ℃; Inert atmosphere;

Reference yield: 68.0%

S-tert-butylsulfinimide (146374-27-8) + cyclopentanone (120-92-3) → 2-methyl-propane-2-sulfinic acid cyclopentylideneamide (899440-18-7,891782-29-9)

Guidance literature:

With titanium(IV) tetraethanolate; In tetrahydrofuran; for 6h; Heating;

DOI:10.1055/s-2006-926449

upstream raw materials:

S-tert-butylsulfinimide

cyclopentanone

(R)-2-methylpropane-2-sulfinamide

(S)-2-methylpropane-2-sulfinamide

Refernces

• 1、 -. "FUSED HEXACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY". Page/Page column 103. . Retrieved 2017/11/01.
• 2、 Dawood, Rafid S.,Georgiou, Irene,Wilkie, Ross P.,Lewis, William,Stockman, Robert A.. "Asymmetric Synthesis of Pyrrolidine-Containing Chemical Scaffolds via Tsuji–Trost Allylation of N-tert-Butanesulfinyl Imines". supporting information. p. 11153 - 11158. Retrieved 2017/08/22.