(S)-1,3-DiMethylpiperazine dihydrochloride

Base Information

• Chemical Name: (S)-1,3-DiMethylpiperazine dihydrochloride
• CAS No.: 1152110-30-9
• Molecular Formula: C6H16Cl2N2
• Molecular Weight: 187.11064
• Hs Code.: 2933399990
• Mol file: 1152110-30-9.mol

Synonyms:(S)-1,3-DiMethylpiperazine dihydrochloride

Chemical Property of (S)-1,3-DiMethylpiperazine dihydrochloride

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(3s)-1,3-DimethylpiperazineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3s)-1,3-Dimethylpiperazine Dihydrochloride is useful for the preparation of triazolopyrimidine compounds, which get evaluated for anti-cancer activity.

Technology Process of (S)-1,3-DiMethylpiperazine dihydrochloride

There total 2 articles about (S)-1,3-DiMethylpiperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(3R)-1,3-dimethyl-2,5-piperazinedione (66445-41-8) → (3R)-1,3-dimethylpiperazine dihydrochloride (1152110-30-9,1022094-05-8,1152110-26-3)

Guidance literature:

(3R)-1,3-dimethyl-2,5-piperazinedione; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 65 ℃; for 3.5h;

With sodium hydroxide; sodium sulfate; In tetrahydrofuran; water;

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

tert-butyl 2,4-dimethylpiperazine-1-carboxylate → 1,3-dimethylpiperazine hydrochloride (1152110-30-9,1022094-05-8,1152110-26-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 2h;

Reference yield: 30.0%

(3S)-1,3-dimethylpiperazine dihydrochloride (1152110-30-9,1022094-05-8,1152110-26-3) + 3-[(chloroacetyl)amino]-N-[6-(2-fluorophenyl)pyridin-3-yl]-4-(trifluoromethoxy)benzamide → 3-({[(2S)-2,4-dimethylpiperazin-1-yl]acetyl}amino)-N-[6-(2-fluorophenyl)pyridin-3-yl]-4-(trifluoromethoxy)benzamide

Guidance literature:

With triethylamine; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

(3R)-1,3-dimethyl-2,5-piperazinedione

Downstream raw materials:

2,4-Dimethyl-piperazin-1-ylamine

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