2,4,5-TRIFLUOROMANDELIC ACID

Base Information

• Chemical Name: 2,4,5-TRIFLUOROMANDELIC ACID
• CAS No.: 375369-29-2
• Molecular Formula: C8H5F3O3
• Molecular Weight: 206.121
• Mol file: 375369-29-2.mol

Synonyms:2,4,5-TRIFLUOROMANDELIC ACID

Chemical Property of 2,4,5-TRIFLUOROMANDELIC ACID

Chemical Property:

• Vapor Pressure: 0.00039mmHg at 25°C
• Boiling Point: 304.2°C at 760 mmHg
• Flash Point: 137.8°C
• PSA: 57.53000
• Density: 1.613g/cm³
• LogP: 1.22190

Purity/Quality:

98%min ^*data from raw suppliers

2,4,5-Trifluoromandelicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-TRIFLUOROMANDELIC ACID

There total 3 articles about 2,4,5-TRIFLUOROMANDELIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

dichloroacethyl chloride (79-36-7) + 1,2,4-trifluorobenzene (367-23-7) → 2,4,5-trifluoromandelic acid (375369-29-2)

Guidance literature:

dichloroacethyl chloride; 1,2,4-trifluorobenzene; aluminum (III) chloride; at 60 ℃;

With sodium hydroxide; water; at 60 ℃;

With hydrogenchloride; In water; at 0 - 20 ℃; pH=1;

Reference yield:

2,4,5-trifluoro-α,α-dichloroacetophenone → 2,4,5-trifluoromandelic acid (375369-29-2)

Guidance literature:

With water; sodium hydroxide; In dichloromethane; at 40 ℃; for 1h; Solvent;

Reference yield:

1,2,4-trifluorobenzene (367-23-7) → 2,4,5-trifluoromandelic acid (375369-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 4.5 h / 60 °C / Inert atmosphere

2: sodium hydroxide; water / dichloromethane / 1 h / 40 °C

With aluminum (III) chloride; water; sodium hydroxide; In dichloromethane;

upstream raw materials:

dichloroacethyl chloride

1,2,4-trifluorobenzene

Downstream raw materials:

2-(2,4,5-trifluorophenyl)-2-chloroacetic acid

methyl 2,4,5-trifluoromandelate

(2,4,5-trifluorophenyl)acetic acid