6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Base Information

Chemical Name:6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin
CAS No.:77380-35-9
Molecular Formula:C19H20F2N2S
Molecular Weight:0
Hs Code.:
Mol file:77380-35-9.mol

Synonyms:6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin;VUFB-13716

Suppliers and Price of 6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

Chemical Property:

PSA：31.78000
LogP:3.83640

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

There total 7 articles about 6,9-Difluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 109-01-3
1-methyl-piperazine

: 77380-33-7
11-chloro-1,4-difluoro-10,11-dihydrodibenzothiepin

: 77380-34-8
1,4-difluorodibenzothiepin

: 77380-35-9
1,4-difluoro-11-(4-methylpiperazino)-10,11-dihydrodibenzothiepin

Guidance literature:: In chloroform; for 8h; Heating;
DOI:10.1135/cccc19802688

Reference yield:

: 18698-96-9
o-iodophenylacetic acid

: 77380-35-9
1,4-difluoro-11-(4-methylpiperazino)-10,11-dihydrodibenzothiepin

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / KOH, Cu / H₂O / 16 h / Heating

2: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C

3: 94 percent / NaBH₄, aq. NaOH / ethanol; benzene / 4 h / Heating

4: 97 percent / HCl, CaCl₂ / benzene / Ambient temperature

5: 67 percent / CHCl₃ / 8 h / Heating

With hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; PPA; copper; calcium chloride; In ethanol; chloroform; water; benzene;
DOI:10.1135/cccc19802688

Reference yield:

: 367-30-6
2,5-difluoroaniline

: 77380-35-9
1,4-difluoro-11-(4-methylpiperazino)-10,11-dihydrodibenzothiepin

Guidance literature:: Multi-step reaction with 6 steps

2: 64 percent / KOH, Cu / H₂O / 16 h / Heating

3: 3.60 g / polyphosphoric acid / 2.5 h / 120 - 125 °C

4: 94 percent / NaBH₄, aq. NaOH / ethanol; benzene / 4 h / Heating

5: 97 percent / HCl, CaCl₂ / benzene / Ambient temperature

6: 67 percent / CHCl₃ / 8 h / Heating

With hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; PPA; copper; calcium chloride; In ethanol; chloroform; water; benzene;
DOI:10.1135/cccc19802688