endo-Fenchylamine

Base Information

• Chemical Name: endo-Fenchylamine
• CAS No.: 5003-94-1
• Molecular Formula: C₁₀H₁₉N
• Molecular Weight: 153.268
• Mol file: 5003-94-1.mol

Synonyms:endo-Fenchylamine

Chemical Property of endo-Fenchylamine

Chemical Property:

• Boiling Point: 188.9±8.0 °C(Predicted)
• PKA: 11.17±0.60(Predicted)
• Density: 0.923±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of endo-Fenchylamine

There total 2 articles about endo-Fenchylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-fenchone (18492-37-0,126-21-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → 1,3,3-trimethylbicyclo<2.2.1>heptan-2-endo-amine (4895-45-8,5003-94-1,21252-46-0,131348-01-1,131348-06-6,131348-10-2,131348-11-3,770696-39-4)

Guidance literature:

With formic acid; at 185 ℃; und Erwaermen einer Loesung des danach isolierten Reaktionsprodukts in Benzol mit wss.Salzsaeure;

DOI:10.1021/ja01300a089 DOI:10.1021/ja01151a109

Reference yield:

(+/-)-N-(1,3,3-trimethyl-[2endo]norbornyl)-formamide (6622-69-1,131348-00-0,131348-04-4,131348-08-8,131348-09-9) → 1,3,3-trimethylbicyclo<2.2.1>heptan-2-endo-amine (4895-45-8,5003-94-1,21252-46-0,131348-01-1,131348-06-6,131348-10-2,131348-11-3,770696-39-4)

Guidance literature:

(acid hydrolysis);

DOI:10.1021/jm01239a001

Reference yield:

1,3,3-trimethylbicyclo<2.2.1>heptan-2-endo-amine (4895-45-8,5003-94-1,21252-46-0,131348-01-1,131348-06-6,131348-10-2,131348-11-3,770696-39-4) → 4-Amino-benzoic acid 2-[methyl-((1R,2R,4S)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / H₂O / 1 h / 100 °C / closed vessel

2: 2.) 2M NaOH / 1.) 98percent formic acid, boiled, 4 h, 2.) ethanol, reflux, 1 h

3: 86 percent / pyridine / 0.33 h / 70 °C

4: 84 percent / hydrogen / PtO₂ / ethyl acetate / 1 h / Ambient temperature

With pyridine; sodium hydroxide; hydrogen; platinum(IV) oxide; In water; ethyl acetate;

upstream raw materials:

(+/-)-fenchone

formamide

(+/-)-N-(1,3,3-trimethyl-[2endo]norbornyl)-formamide

Downstream raw materials:

(1S)-endo-fenchylamine

(+)-endo-Fenchylamine

(+/-)-2endo-salicylidenamino-1.3.3-trimethyl-norbornane

(1R)-2endo-salicylidenamino-1.3.3-trimethyl-norbornane