Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-

Base Information

• Chemical Name: Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-
• CAS No.: 169396-92-3
• Molecular Formula: C26H26N4O7
• Molecular Weight: 506.50724
• Mol file: 169396-92-3.mol

Synonyms:Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-;{[2-(9H-Fluoren-9-ylMethoxycarbonylaMino)-ethyl]-[2-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyriMidin-1-yl)-acetyl]-aMino}-acetic acid;Fmoc-PNA-T-OH;Fmoc-PNA-thymine-OH

Chemical Property of Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-

Chemical Property:

• PKA: 3.33±0.10(Predicted)
• PSA: 150.80000
• Density: 1.368±0.06 g/cm3(Predicted)
• LogP: 1.68780

Purity/Quality:

≥97%,≥99%, ^*data from raw suppliers

Fmoc-PNA-T-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-

There total 13 articles about Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl N-<2-(N-9-fluorenylmethoxycarbonyl)aminoethyl>-N-<(thymin-1-yl)acetyl>glycinate → 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid (169396-92-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/0040-4020(95)00286-H

Reference yield: 90.2%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + methyl N-[2-(fluorenylmethoxycarbonyl)aminoethyl]-N-[(thymine-1-yl)acetyl]glycinate (172405-62-8) → 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid (169396-92-3)

Guidance literature:

methyl N-[2-(fluorenylmethoxycarbonyl)aminoethyl]-N-[(thymine-1-yl)acetyl]glycinate; With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 0 - 25 ℃; for 0.5h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In tetrahydrofuran; water; at 0 - 25 ℃; pH=8;

DOI:10.1002/ejoc.202100278

Reference yield: 85.0%

ethyl 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetate (1378894-94-0) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid (169396-92-3)

Guidance literature:

ethyl 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetate; With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In tetrahydrofuran; for 12h;

DOI:10.1071/CH11471

upstream raw materials:

methyl N-[2-(fluorenylmethoxycarbonyl)aminoethyl]-N-[(thymine-1-yl)acetyl]glycinate

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

N-(2-t-butoxycarbonylaminoethyl)-N-(thymin-1-ylacetyl)glycine

thymidyl acetic acid

Downstream raw materials:

{[4-(2-{[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-pyridin-3-ylmethyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid benzyl ester

C₄₈H₅₂N₈O₁₃

C₁₁₅H₁₅₀N₃₈O₄₀S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 169396-92-3 Glycine, N-[2-(3,4-dihydro-5-Methyl-2,4-dioxo-1(2H)-pyriMidinyl)acetyl]-N-[2-[[(9H-fluoren-9-ylMethoxy)carbonyl]aMino]ethyl]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send