DTP348

Base Information

• Chemical Name: DTP348
• CAS No.: 1383370-92-0
• Molecular Formula: C6H11N5O4S
• Molecular Weight: 249.25
• Mol file: 1383370-92-0.mol

Synonyms:DTP348

Chemical Property of DTP348

Chemical Property:

• PSA: 144.21000
• LogP: 1.58800

Purity/Quality:

98% ^*data from raw suppliers

1-(2-Sulfamidoethyl)-2-methyl-5-nitroimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-Sulfamidoethyl)-2-methyl-5-nitroimidazole is a hypoxia-targeting carbonic anhydrase IX inhibitor.

Technology Process of DTP348

There total 2 articles about DTP348 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(2-methyl-5-nitro-imidazol-3-ium-1-yl)ethylammonium dichloride (49575-10-2) → N-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]sulfamide (1383370-92-0)

Guidance literature:

2-(2-methyl-5-nitro-imidazol-3-ium-1-yl)ethylammonium dichloride; With isocyanate de chlorosulfonyle; triethylamine; tert-butyl alcohol; In dichloromethane; at 20 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

C7H9N5O5S → N-[2-(2-methyl-5-nitro-imidazol-1-yl)ethyl]sulfamide (1383370-92-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jm4009532

upstream raw materials:

2-(2-methyl-5-nitro-imidazol-3-ium-1-yl)ethylammonium dichloride