(4aS,6aS,6bR,8aS,10S,12aS,14aS,14bS)-10-hydroxy-2,2,6b,9,9,12a,14a-hep tamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a- carboxylic acid

Base Information

• Chemical Name: (4aS,6aS,6bR,8aS,10S,12aS,14aS,14bS)-10-hydroxy-2,2,6b,9,9,12a,14a-hep tamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a- carboxylic acid
• CAS No.: 29099-34-1
• Molecular Formula: C₃₀H₄₈O₃
• Molecular Weight: 456.709
• Mol file: 29099-34-1.mol

Synonyms:(4aS,6aS,6bR,8aS,10S,12aS,14aS,14bS)-10-hydroxy-2,2,6b,9,9,12a,14a-hep tamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a- carboxylic acid;maprounic acid;Maprounic acid B805169K075;Nsc359426

Chemical Property of (4aS,6aS,6bR,8aS,10S,12aS,14aS,14bS)-10-hydroxy-2,2,6b,9,9,12a,14a-hep tamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a- carboxylic acid

Chemical Property:

• Vapor Pressure: 1.01E-14mmHg at 25°C
• Boiling Point: 556.9°C at 760 mmHg
• Flash Point: 304.7°C
• Density: 1.09g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4aS,6aS,6bR,8aS,10S,12aS,14aS,14bS)-10-hydroxy-2,2,6b,9,9,12a,14a-hep tamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a- carboxylic acid

There total 7 articles about (4aS,6aS,6bR,8aS,10S,12aS,14aS,14bS)-10-hydroxy-2,2,6b,9,9,12a,14a-hep tamethyl-1,3,4,5,6a,7,8,8a,10,11,12,13,14,14b-tetradecahydropicene-4a- carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.9%

3α-(3''-,4''-dihydroxy-trans-cinnamoyloxy)-D-friedoolean-14-en-28-oic acid → 3α-hydroxytaraxer-14-en-28-oic acid (29099-34-1)

Guidance literature:

With nitric acid; sodium hydroxide; In methanol; at 20 ℃; for 24h; pH=5 - 6;

DOI:10.1080/10286020.2013.787990

Reference yield: 40.0%

3α-hydroxytaraxer-14-en-28-oic acid (29099-34-1) → aleuritolic acid (108906-72-5,26549-17-7,29099-34-1)

Guidance literature:

With 2,2-dimethylsuccinic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere; Cooling with ice;

DOI:10.1080/10286020.2013.787990

Reference yield:

3-O-acetyl aleuritolic acid (28937-85-1) → aleuritolic acid (108906-72-5,26549-17-7,29099-34-1)

Guidance literature:

With potassium hydroxide; In methanol; for 24h; Ambient temperature;

DOI:10.1016/0031-9422(88)84109-8

upstream raw materials:

3-O-acetyl aleuritolic acid

3-acetylaleuritolic acid

Downstream raw materials:

aleuritolic acid