3-(N-Methylamino)-2,6-dichloropyridine

Base Information

• Chemical Name: 3-(N-Methylamino)-2,6-dichloropyridine
• CAS No.: 142670-86-8
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.033
• Mol file: 142670-86-8.mol

Synonyms:3-(N-Methylamino)-2,6-dichloropyridine

Chemical Property of 3-(N-Methylamino)-2,6-dichloropyridine

Chemical Property:

• PSA: 24.92000
• LogP: 2.50310

Purity/Quality:

99%min ^*data from raw suppliers

(2,6-Dichloro-pyridin-3-yl)-methyl-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(N-Methylamino)-2,6-dichloropyridine

There total 4 articles about 3-(N-Methylamino)-2,6-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(N-Methyl-N-acetamino)-2-chloropyridine → 3-(N-Methylamino)-2,6-dichloropyridine (142670-86-8)

Guidance literature:

With hydrogenchloride; In ethanol; Heating;

Reference yield:

3-amino-2,6-dichloropyridine (62476-56-6) → 3-(N-Methylamino)-2,6-dichloropyridine (142670-86-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene

2: NaH / dimethylformamide

3: 3N HCl / ethanol / Heating

With hydrogenchloride; sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

3-Acetamino-2-chloropyridine (76175-82-1) → 3-(N-Methylamino)-2,6-dichloropyridine (142670-86-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 3N HCl / ethanol / Heating

With hydrogenchloride; sodium hydride; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

3-amino-2,6-dichloropyridine

3-Acetamino-2-chloropyridine

Downstream raw materials:

N-Methyl-6-chloro-3-phenyl-2-diphenylphosphinoyl-1H-pyrido<2,3-b><1,4>thiazine

2-(N-Methyl-N-diphenylphosphinoylmethylamino)-2,6-dichloropyridine

Refernces

• 1、 Couture, Axel,Deniau, Eric,Crandclaudon, Pierre. "SYNTHESE DE N-ALKYL-3-ARYL-2-DIPHENYLPHOSPHINOYL-1H-PYRIDOTHIAZINES". . p. 91 - 98. Retrieved 2007/10/02.