CCG-100602

Base Information

• Chemical Name: CCG-100602
• CAS No.: 1207113-88-9
• Molecular Formula: C₂₁H₁₇ClF₆N₂O₂
• Molecular Weight: 478.822
• Mol file: 1207113-88-9.mol

Synonyms:CCG-100602

Chemical Property of CCG-100602

Chemical Property:

• PSA: 49.41000
• LogP: 5.87940

Purity/Quality:

99%, ^*data from raw suppliers

CCG-100602 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. The site of inhibition in the pathway is not precisely defined but CCG-1423 appears to act on some aspect of the interaction of SRF with its transcriptional cofactor megakaryoblastic leukemia 1 (MKL1) at a point upstream of DNA binding. CCG-100602 is a CCG-1423 analog developed for improved selectivity, potency, and attenuated cytotoxicity relative to its parent compound. CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells with an IC50 value of 9.8 μM. At 100 μM, CCG-100602 demonstrates 72% inhibition of PC-3 cell invasion into a Matrigel model of metastasis, exhibiting an efficacy:toxicity profile superior to that of CCG-1423 at 10 μM.[Cayman Chemical]

Technology Process of CCG-100602

There total 1 articles about CCG-100602 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H13F6NO3 (1054120-17-0) + 4-chloro-aniline (106-47-8) → CCG-100602 (1207113-88-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2009.11.056

upstream raw materials:

C₁₅H₁₃F₆NO₃

4-chloro-aniline

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