tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Base Information

Chemical Name:tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide
CAS No.:1340481-83-5
Molecular Formula:C₁₁H₂₀N₂O₄S
Molecular Weight:276.357
Hs Code.:2922390090
Mol file:1340481-83-5.mol

Synonyms:tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide;2-Boc-8-amino-5-thia-2-azaspiro[3.4]octane 5,5-dioxide 95%

Suppliers and Price of tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-butyl8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate5,5-dioxide
2mg
$ 65.00

Sigma-Aldrich
2-Boc-8-amino-5-thia-2-azaspiro[3.4]octane 5,5-dioxide 95%
100mg
$ 549.00

Crysdot
tert-Butyl8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate5,5-dioxide 95+%
5g
$ 4286.00

Crysdot
tert-Butyl8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate5,5-dioxide 95+%
1g
$ 1429.00

Chemenu
tert-Butyl8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate5,5-dioxide 95%
1g
$ 1346.00

American Custom Chemicals Corporation
TERT-BUTYL-8-AMINO-5-THIA-2-AZASPIRO-[3.4]OCTANE-2-CARBOXYLATE-5,5-DIOXIDE 95.00%
5MG
$ 495.18

AK Scientific
2-Boc-8-amino-5-thia-2-azaspiro[3.4]octane 5,5-dioxide
100mg
$ 744.00

Total 12 raw suppliers

Chemical Property of tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Chemical Property:

PSA：98.08000
LogP:1.84070
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate5,5-dioxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Spirocyclic building block was first synthesized by Carreira and coworkers, which provides a new area of chemical space with straightforward functional handles for further diversification.

Technology Process of tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

There total 8 articles about tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1340481-82-4
C₁₉H₂₆N₂O₆S

: 1340481-83-5
C₁₁H₂₀N₂O₄S

Guidance literature:: With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol2025313

Reference yield:

: 398489-26-4
tert-butyl 3-oxoazetidine-1-carboxylate

: 1340481-83-5
C₁₁H₂₀N₂O₄S

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / Inert atmosphere; Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

6.1: diphenyl phosphoryl azide; triethylamine / toluene / 20 °C / Inert atmosphere; Reflux

7.1: toluene / Inert atmosphere; Reflux

8.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene; 6.1: Curtius rearrangement;
DOI:10.1021/ol2025313

Reference yield:

: 1340481-78-8
C₁₂H₁₉NO₄S

: 1340481-83-5
C₁₁H₂₀N₂O₄S

Guidance literature:: Multi-step reaction with 7 steps

1: methanesulfonyl chloride; triethylamine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / Inert atmosphere; Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

4: lithium hydroxide / tetrahydrofuran; water / 1 h / 0 °C / Inert atmosphere

5: diphenyl phosphoryl azide; triethylamine / toluene / 20 °C / Inert atmosphere; Reflux

6: toluene / Inert atmosphere; Reflux

7: palladium on activated charcoal; hydrogen / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 5: Curtius rearrangement;
DOI:10.1021/ol2025313