L-A-PHOSPHATIDYLINOSITOL

Base Information

• Chemical Name: L-A-PHOSPHATIDYLINOSITOL
• CAS No.: 119943-95-2
• Molecular Formula: C41H78NaO13P
• Molecular Weight: 833.026
• Mol file: 119943-95-2.mol

Synonyms:L-A-PHOSPHATIDYLINOSITOL;PtdIns diC 16

Chemical Property of L-A-PHOSPHATIDYLINOSITOL

Chemical Property:

• PSA: 222.15000
• LogP: 8.16250
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

L-a-Phosphatidylinositol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-A-PHOSPHATIDYLINOSITOL

There total 11 articles about L-A-PHOSPHATIDYLINOSITOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(+)-1D-2,4,5,6-tetra-O-benzyl-3-O-(4'-methoxybenzyl)-myo-inositol-1-(1',2'-di-O-hexadecanoyl-sn-glycer-3'-yl benzyl phosphate) (1207434-93-2) → 1D-myo-inositol-1-(1',2'-di-O-hexadecanoyl-sn-glycer-3'-yl sodium phosphate) (119943-95-2)

Guidance literature:

With hydrogen; sodium hydrogencarbonate; palladium; In water; tert-butyl alcohol; at 20 ℃; for 48h; under 7500.75 Torr;

DOI:10.1039/b913399b

Reference yield:

1-O-(tert-butyldiphenylsilyl)-4-O-camphanyl-2,3:5,6-di-O-isopropylidene-D-myo-inositol (119874-36-1,119943-92-9) → 1D-myo-inositol-1-(1',2'-di-O-hexadecanoyl-sn-glycer-3'-yl sodium phosphate) (119943-95-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / KOH / ethanol

2: 87 percent / pyridinium p-toluenesulphonate / CH₂Cl₂

3: 85 percent / TBAF / tetrahydrofuran

4: 80 percent / MSNT, pyridine

5: H₂ / PtO₂ / ethanol

6: 1.) H₂O, 2.) amberlite IRC-50 / 1.) EtOH, 2.) aq. EtOH,

With pyridine; potassium hydroxide; MSNT; Amberlite IRC-50; tetrabutyl ammonium fluoride; water; hydrogen; pyridinium p-toluenesulfonate; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/S0040-4039(00)82254-6

Reference yield:

sodium salt of 1,2-di-O-palmitoyl-sn-glycer-3-yl phenylphosphate (124581-40-4) → 1D-myo-inositol-1-(1',2'-di-O-hexadecanoyl-sn-glycer-3'-yl sodium phosphate) (119943-95-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / MSNT, pyridine

2: H₂ / PtO₂ / ethanol

3: 1.) H₂O, 2.) amberlite IRC-50 / 1.) EtOH, 2.) aq. EtOH,

With pyridine; MSNT; Amberlite IRC-50; water; hydrogen; platinum(IV) oxide; In ethanol;

DOI:10.1016/S0040-4039(00)82254-6

upstream raw materials:

1-O-(tert-butyldiphenylsilyl)-4-O-camphanyl-2,3:5,6-di-O-isopropylidene-D-myo-inositol

sodium salt of 1,2-di-O-palmitoyl-sn-glycer-3-yl phenylphosphate

2,3:5,6-di-O-isopropylidene-4-O-(4-methoxytetrahydropyran-4-yl)-D-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-glycer-3-yl phenyl phosphate)

4-O-(4-methoxytetrahydropyran-4-yl)-2,3:5,6-di-O-isopropylidene-D-myo-inositol

Refernces

• 1、 Ward, John G.,Young, Rodney C.. "SYNTHESIS OF 1,2-DIPALMITOYL-sn-GLYCER-3-YL-D-myo-INOSITOL 1-PHOSPHATE.". . p. 6013 - 6016. Retrieved 2007/10/02.