(R)-(+)-Tolvaptan

Base Information

Chemical Name:(R)-(+)-Tolvaptan
CAS No.:331947-66-1
Molecular Formula:C26H25ClN2O3
Molecular Weight:448.949
Hs Code.:
Mol file:331947-66-1.mol

Synonyms:(R)-(+)-Tolvaptan

Suppliers and Price of (R)-(+)-Tolvaptan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(+)-Tolvaptan
2.5mg
$ 275.00

American Custom Chemicals Corporation
(R)-(+)-TOLVAPTAN 95.00%
5MG
$ 502.37

Total 10 raw suppliers

Chemical Property of (R)-(+)-Tolvaptan

Chemical Property:

Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(R)-(+)-Tolvaptan ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-(+)-Tolvaptan

There total 9 articles about (R)-(+)-Tolvaptan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 331947-63-8
(R)-7-chloro-5-methoxymethyloxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

: 331947-66-1
(+)-Tolvaptan

Guidance literature:: With hydrogenchloride; In methanol; at 55 ℃; for 1.5h;
DOI:10.3987/COM-99-S(I)2

Reference yield:

: 137973-76-3
MOP-21826

: 331947-66-1
(+)-Tolvaptan

Guidance literature:: With formic acid; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; triethylamine; (1R,2R)-(-)-N-p-tosyl-1,2-cyclohexanediamine; In N,N-dimethyl-formamide; at 30 ℃; for 30h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2010.08.016

Reference yield:

: 137973-76-3
MOP-21826

: 331947-66-1
(+)-Tolvaptan

: 331947-44-5
(-)-Tolvaptan

Guidance literature:: With potassium hydroxide; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; In isopropyl alcohol; at 20 ℃;
DOI:10.3987/COM-00-S(K)4