3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine(SALTDATA: FREE)

Base Information

• Chemical Name: 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine(SALTDATA: FREE)
• CAS No.: 915920-45-5
• Molecular Formula: C₉H₁₆N₂
• Molecular Weight: 152.239
• Mol file: 915920-45-5.mol

Synonyms:3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine(SALTDATA: FREE)

Chemical Property of 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine(SALTDATA: FREE)

Chemical Property:

• PSA: 29.26000
• LogP: 1.23370

Purity/Quality:

3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine(SALTDATA: FREE)

There total 3 articles about 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propanenitrile → 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine (915920-45-5)

Guidance literature:

With lithium aluminium tetrahydride; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.7b01746

Reference yield:

racemic 2-azabicyclo[2.2.1]hept-5-en-3-one (49805-30-3) → 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine (915920-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20.5 h / 0 °C / Inert atmosphere; Reflux

1.2: Inert atmosphere

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.7b01746

Reference yield:

2-azabicyclo[2.2.1]hept-5-en hydrochloride → 3-(2-azabicyclo[2.2.1]hept-5-en-2-yl)propan-1-amine (915920-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; potassium hydrogencarbonate; In N,N-dimethyl-formamide;

DOI:10.1021/acs.orglett.7b01746

upstream raw materials:

racemic 2-azabicyclo[2.2.1]hept-5-en-3-one