(8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde

Base Information

Chemical Name:(8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde
CAS No.:1127424-66-1
Molecular Formula:C9H11NO2
Molecular Weight:165.192
Hs Code.:
Mol file:1127424-66-1.mol

Synonyms:(8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde

Suppliers and Price of (8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde

Chemical Property:

PSA：37.38000
LogP:0.44430

Purity/Quality:

Safty Information:

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Technology Process of (8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde

There total 1 articles about (8aS)-1,2,3,5,6,8a-hexahydro-3-oxo-8-Indolizinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1127424-75-2
(8aS)-8-(1,3-dioxolan-2-yl)-1,5,6,8a-tetrahydro-2H-indolizin-3-one

: 1127424-66-1
(8aS)-3-oxo-1,2,3,5,6,8a-hexahydroindolizine-8-carbaldehyde

Guidance literature:: With water; toluene-4-sulfonic acid; In acetone; for 0.25h; Reflux;
DOI:10.1021/ol900032h

Reference yield: 100.0%

: 1127424-66-1
(8aS)-3-oxo-1,2,3,5,6,8a-hexahydroindolizine-8-carbaldehyde

: 54307-74-3,15466-88-3
(S)-(+)-5-methylcyclohex-2-en-1-one

: 1127424-76-3
(8aS,1'R,6'S)-8-[(S)-hydroxy(6'-methyl-2'-oxo-cyclohex-3'-en-1'-yl)methyl]-1,5,6,8a-tetrahydro-2H-indolizin-3-one

Guidance literature:: (S)-(+)-5-methylcyclohex-2-en-1-one; With di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 1h;

(8aS)-3-oxo-1,2,3,5,6,8a-hexahydroindolizine-8-carbaldehyde; In dichloromethane; at -78 - 20 ℃;

With dihydrogen peroxide; In methanol; dichloromethane; at 4 ℃; stereoselective reaction;
DOI:10.1021/ol900032h