4-(4-Bromophenyl)-1,3-oxazolidin-2-one

Base Information

• Chemical Name: 4-(4-Bromophenyl)-1,3-oxazolidin-2-one
• CAS No.: 85288-37-5
• Molecular Formula: C₉H₈BrNO₂
• Molecular Weight: 242.072
• European Community (EC) Number: 860-462-1
• Mol file: 85288-37-5.mol

Synonyms:4-(4-bromophenyl)-1,3-oxazolidin-2-one;85288-37-5;4-(4-BROMOPHENYL)OXAZOLIDIN-2-ONE;MFCD20132106;2-Oxazolidinone,4-(4-bromophenyl)-;4-(4-Bromo-phenyl)oxazolidin-2-one;AKOS014924344;BS-12574;CS-0245038;C77587;EN300-298500;Z1266873491

Chemical Property of 4-(4-Bromophenyl)-1,3-oxazolidin-2-one

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 240.97384
• Heavy Atom Count: 13
• Complexity: 202

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NC(=O)O1)C2=CC=C(C=C2)Br

Technology Process of 4-(4-Bromophenyl)-1,3-oxazolidin-2-one

There total 9 articles about 4-(4-Bromophenyl)-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-bromophenethyl azidoformate → (-)-4-(4-bromophenyl)oxazolidin-2-one (85288-37-5)

Guidance literature:

With C₁₉H₁₉Cl₃CoNO; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; at 60 ℃; for 12h; chemoselective reaction; Sealed tube;

DOI:10.1021/jacs.0c04448

Reference yield: 58.0%

(+/-)-2-(4-bromophenyl)oxirane (32017-76-8) + sodium isocyanate (917-61-3) → (-)-4-(4-bromophenyl)oxazolidin-2-one (85288-37-5)

Guidance literature:

With potassium dihydrogenphosphate; In dimethyl sulfoxide; at 30 ℃; for 12h;

Reference yield: 56.0%

4-bromophenethyl [{3,5-bis(trifluoromethyl)benzoyl}oxy]carbamate → (-)-4-(4-bromophenyl)oxazolidin-2-one (85288-37-5)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; potassium carbonate; In 1,1,2,2-tetrachloroethane; at 25 ℃; for 12h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.0c00868

upstream raw materials:

(+/-)-2-(4-bromophenyl)oxirane

carbamic acid phenyl ester

sodium isocyanate

4-bromophenethanol