6-BroMo-2-chloro-5-fluoro-quinazoline

Base Information

• Chemical Name: 6-BroMo-2-chloro-5-fluoro-quinazoline
• CAS No.: 1036756-07-6
• Molecular Formula: C8H3BrClFN2
• Molecular Weight: 261.481
• Mol file: 1036756-07-6.mol

Synonyms:6-BroMo-2-chloro-5-fluoro-quinazoline

Chemical Property of 6-BroMo-2-chloro-5-fluoro-quinazoline

Chemical Property:

• Boiling Point: 309.5±35.0 °C(Predicted)
• PKA: -1.01±0.30(Predicted)
• PSA: 25.78000
• Density: 1.836±0.06 g/cm3(Predicted)
• LogP: 3.18480

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-2-chloro-4-fluoroquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-2-chloro-5-fluoro-quinazoline

There total 6 articles about 6-BroMo-2-chloro-5-fluoro-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-bromo-5-fluoroquinazolin-2-ol → 6-bromo-2-chloro-5-fluoroquinazoline (1036756-07-6)

Guidance literature:

With trichlorophosphate; at 135 ℃; for 5h;

Reference yield:

2-amino-6-fluorobenzoic acid (434-76-4) → 6-bromo-2-chloro-5-fluoroquinazoline (1036756-07-6)

Guidance literature:

Multi-step reaction with 5 steps

1: bromine / methanol / 2 h / -78 °C

2: borane-THF / tetrahydrofuran / 0 - 20 °C

3: manganese(IV) oxide / dichloromethane / 20 °C

4: 2 h / 180 °C

5: trichlorophosphate / 5 h / 135 °C

With manganese(IV) oxide; borane-THF; bromine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

6-amino-3-bromo-2-fluorobenzoic acid (1036756-03-2) → 6-bromo-2-chloro-5-fluoroquinazoline (1036756-07-6)

Guidance literature:

Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

3: 2 h / 180 °C

4: trichlorophosphate / 5 h / 135 °C

With manganese(IV) oxide; borane-THF; trichlorophosphate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-amino-6-fluorobenzoic acid

6-amino-3-bromo-2-fluorobenzoic acid

Downstream raw materials:

C₁₇H₁₆BrFN₄

Refernces

• 1、 -. "NEW CHEMICAL COMPOUNDS". Page/Page column 80. . Retrieved 2010/04/03.