Methyl 3,3-difluorocyclopentanecarboxylate

Base Information

• Chemical Name: Methyl 3,3-difluorocyclopentanecarboxylate
• CAS No.: 1394129-94-2
• Molecular Formula: C₇H₁₀F₂O₂
• Molecular Weight: 164.152
• Hs Code.: 2916200090
• Mol file: 1394129-94-2.mol

Synonyms:Methyl 3,3-difluorocyclopentanecarboxylate;methyl 3,3-difluorocyclopentane-1-carboxylate

Chemical Property of Methyl 3,3-difluorocyclopentanecarboxylate

Chemical Property:

• PSA: 26.30000
• LogP: 1.59480
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3,3-Difluorocyclopentanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3,3-difluorocyclopentanecarboxylate

There total 2 articles about Methyl 3,3-difluorocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-oxocyclopentane-1-carboxylate (32811-75-9) → methyl 3,3-difluorocyclopentane-1-carboxylate (1394129-94-2,1408002-87-8)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In ethanol; dichloromethane; at 0 - 30 ℃; for 48h;

Reference yield:

3-Oxo-cyclopentanecarboxylic acid (98-78-2) → methyl 3,3-difluorocyclopentane-1-carboxylate (1394129-94-2,1408002-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 0 - 60 °C / Inert atmosphere

2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; ethanol / 48 h / 0 - 30 °C

With potassium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In ethanol; dichloromethane; acetone;

Reference yield:

methyl 3,3-difluorocyclopentane-1-carboxylate (1394129-94-2,1408002-87-8) → ethyl 3-(4-[[3-(3,3-difluorocyclopentyl)-5-(trifluoromethyl)-1,2-thiazol-4-yl]methoxy]-2,3-dimethylphenyl)propanoate

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium hydroxide / methanol; water / 25 °C

2: 100 °C

3: 160 °C / Sealed tube

4: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C

5: toluene / Inert atmosphere

With ammonium hydroxide; lithium aluminium tetrahydride; In methanol; diethyl ether; water; toluene;

upstream raw materials:

methyl 3-oxocyclopentane-1-carboxylate

3-Oxo-cyclopentanecarboxylic acid

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