5,7,4'-Trihydroxy-8-Methylflavanone

Base Information

• Chemical Name: 5,7,4'-Trihydroxy-8-Methylflavanone
• CAS No.: 916917-28-7
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.284
• Mol file: 916917-28-7.mol

Synonyms:5,7,4'-Trihydroxy-8-Methylflavanone;methyl-4H-1-benzopyran-4-one

Chemical Property of 5,7,4'-Trihydroxy-8-Methylflavanone

Chemical Property:

• Boiling Point: 570.2±50.0 °C (760 mmHg)
• PSA: 86.99000
• Density: 1.434±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.81830

Purity/Quality:

≥98% ^*data from raw suppliers

5,7,4'-Trihydroxy-8-Methylflavanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-8-methylchroman-4-one is a phenolic derivative of Qualea grandiflora and Qualea cordata.

Technology Process of 5,7,4'-Trihydroxy-8-Methylflavanone

There total 7 articles about 5,7,4'-Trihydroxy-8-Methylflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

8-methyl-5,7,4'-tris(methoxymethoxy)flavanone (916917-16-3) → (+/-)-8-Methylnaringenin (916917-28-7)

Guidance literature:

With hydrogenchloride; In methanol; Heating;

DOI:10.1021/jm060692n

Reference yield:

3'-methyl-2'-hydroxy-4,4',6'-tris(methoxymethoxy)chalcone → (+/-)-8-Methylnaringenin (916917-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / NaOAc / ethanol; H₂O / 20 h / Heating

2: 93 percent / aq. HCl / methanol / Heating

With hydrogenchloride; sodium acetate; In methanol; ethanol; water;

DOI:10.1021/jm060692n

Reference yield:

2,4,6-trihydroxy-3-methyl-acetophenon (2657-28-5) → (+/-)-8-Methylnaringenin (916917-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 64 percent / K₂CO₃ / acetone / 1 h / Heating

2: 74 percent / KOH / ethanol; H₂O / 23 h / 0 - 20 °C

3: 53 percent / NaOAc / ethanol; H₂O / 20 h / Heating

4: 93 percent / aq. HCl / methanol / Heating

With hydrogenchloride; potassium hydroxide; sodium acetate; potassium carbonate; In methanol; ethanol; water; acetone; 2: Claisen-Schmidt condensation;

DOI:10.1021/jm060692n

upstream raw materials:

8-methyl-5,7,4'-tris(methoxymethoxy)flavanone

2,4,6-trihydroxy-3-methyl-acetophenon

2,4,6-trimethoxytoluene

1-(2,4,6-trimethoxy-3-methylphenyl)ethan-1-one

Refernces