1-Pyrrolidineethanol,3-fluoro-,(3R)-(9CI)

Base Information

• Chemical Name: 1-Pyrrolidineethanol,3-fluoro-,(3R)-(9CI)
• CAS No.: 744207-73-6
• Molecular Formula: C6H12FNO
• Molecular Weight: 133.16
• Mol file: 744207-73-6.mol

Synonyms:1-Pyrrolidineethanol,3-fluoro-,(3R)-(9CI);(3R)-3-fluoro-1-Pyrrolidineethanol

Chemical Property of 1-Pyrrolidineethanol,3-fluoro-,(3R)-(9CI)

Chemical Property:

• PSA: 23.47000
• LogP: -0.03960

Purity/Quality:

(3R)-3-fluoro-1-Pyrrolidineethanol 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidineethanol,3-fluoro-,(3R)-(9CI)

There total 2 articles about 1-Pyrrolidineethanol,3-fluoro-,(3R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[(3R)-3-fluoropyrrolidin-1-yl]acetate (1608160-03-7) → 2-[(3R)-3-fluoropyrrolidin-1-yl]ethanol (744207-73-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; for 2h;

Reference yield:

Acetic acid 2-((R)-3-fluoro-pyrrolidin-1-yl)-2-oxo-ethyl ester → 2-[(3R)-3-fluoropyrrolidin-1-yl]ethanol (744207-73-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1016/j.bmcl.2004.05.073

Reference yield:

4-chloro-3-iodo-5-phenyl-1H-pyrazolo[3,4-c]pyridazine (1606126-41-3) + 2-[(3R)-3-fluoropyrrolidin-1-yl]ethanol (744207-73-6) → 4-chloro-1-[2-[(3R)-3-fluoropyrrolidin-1-yl]ethyl]-3-iodo-5-phenylpyrazolo[3,4-c]pyridazine (1608158-61-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 85 ℃; for 1h;

upstream raw materials:

methyl 2-[(3R)-3-fluoropyrrolidin-1-yl]acetate

Downstream raw materials:

4-chloro-1-[2-[(3R)-3-fluoropyrrolidin-1-yl]ethyl]-3-iodo-5-phenylpyrazolo[3,4-c]pyridazine

Refernces

• 1、 Blizzard, Timothy A.,DiNinno, Frank,Morgan II, Jerry D.,Wu, Jane Y.,Chen, Helen Y.,Kim, Seongkon,Chan, Wanda,Birzin, Elizabeth T.,Yang, Yi Tien,Pai, Lee-Yuh,Zhang, Zhoupeng,Hayes, Edward C.,DaSilva, Carolyn A.,Tang, Wei,Rohrer, Susan P.,Schaeffer, James M.,Hammond, Milton L.. "Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains". . p. 3865 - 3868. Retrieved 2007/10/03.