(5-amino-2,3-dimethoxyphenyl)methanol

Base Information

• Chemical Name: (5-amino-2,3-dimethoxyphenyl)methanol
• CAS No.: 1111236-54-4
• Molecular Formula: C9H13NO3
• Molecular Weight: 183.207
• Hs Code.: 2922509090
• Mol file: 1111236-54-4.mol

Synonyms:(5-amino-2,3-dimethoxyphenyl)methanol;5-Amino-2,3-dimethoxybenzenemethanol

Chemical Property of (5-amino-2,3-dimethoxyphenyl)methanol

Chemical Property:

• Boiling Point: 346℃
• PKA: 14.06±0.10(Predicted)
• Flash Point: 163℃
• PSA: 64.71000
• Density: 1.193
• LogP: 1.35950
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(5-Amino-2,3-dimethoxyphenyl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-amino-2,3-dimethoxyphenyl)methanol

There total 1 articles about (5-amino-2,3-dimethoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3-dimethoxy-5-nitro-benzyl alcohol (159873-66-2) → C9H13NO3 (1111236-54-4)

Guidance literature:

2,3-dimethoxy-5-nitro-benzyl alcohol; With thiophene; hydrogen; platinum on carbon; In methanol; di-isopropyl ether; at 20 ℃; for 20h;

With hydrogenchloride; In diethyl ether; at 20 ℃;

Reference yield: 81.0%

7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (208459-84-1) + C9H13NO3 (1111236-54-4) → C21H19IN4O5S (1111236-56-6)

Guidance literature:

7-Benzenesulfonyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine; C₉H₁₃NO₃; With hydrogenchloride; In 1,4-dioxane; tert-butyl alcohol; at 80 ℃; for 72h;

With triethylamine; In water;

Reference yield: 59.4%

C9H13NO3 (1111236-54-4) + 2-chloro-4-(2-chloro-4-pyridinyl)pyrimidine (1150111-29-7) → C18H17ClN4O3 (1187660-47-4)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 20h;

upstream raw materials:

2,3-dimethoxy-5-nitro-benzyl alcohol

Downstream raw materials:

C₂₁H₁₉IN₄O₅S

C₁₈H₁₇ClN₄O₃

C₃₆H₅₁N₇O₆

Refernces

• 1、 -. "4-ARYL-2-ANILINO-PYRIMIDINES AS PLK KINASE INHIBITORS". Page/Page column 74-75. . Retrieved 2009/10/22.