4-Amino-6-bromo-2-phenylquinoline

Base Information

• Chemical Name: 4-Amino-6-bromo-2-phenylquinoline
• CAS No.: 856046-33-8
• Molecular Formula: C₁₅H₁₁BrN₂
• Molecular Weight: 299.17
• ChEMBL ID: CHEMBL2448860
• DSSTox Substance ID: DTXSID50590567
• Wikidata: Q82484215
• Mol file: 856046-33-8.mol

Synonyms:4-Amino-6-bromo-2-phenylquinoline;856046-33-8;SCHEMBL437369;CHEMBL2448860;DTXSID50590567;6-bromo-2-phenylquinolin-4-amine;MFCD07700216;AKOS006056538

Chemical Property of 4-Amino-6-bromo-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 7.17E-10mmHg at 25°C
• Melting Point: 209 °C
• Boiling Point: 493.2°C at 760 mmHg
• PKA: 7.89±0.13(Predicted)
• Flash Point: 252.1°C
• PSA: 38.91000
• Density: 1.491g/cm³
• LogP: 4.82770
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 298.01056
• Heavy Atom Count: 18
• Complexity: 278

Purity/Quality:

97% ^*data from raw suppliers

4-AMINO-6-BROMO-2-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC3=C(C=C(C=C3)Br)C(=C2)N

Technology Process of 4-Amino-6-bromo-2-phenylquinoline

There total 6 articles about 4-Amino-6-bromo-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-bromo-2-phenyl-[4]quinolyl)-carbamic acid ethyl ester (415716-05-1) → 6-bromo-2-phenyl-[4]quinolylamine (856046-33-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1002/ardp.19362740405

Reference yield:

6-bromo-2-phenyl-quinoline-4-carboxylic acid (33007-99-7) → 6-bromo-2-phenyl-[4]quinolylamine (856046-33-8)

Guidance literature:

Multi-step reaction with 5 steps

2: N₂H₄+H₂O

3: aqueous HCl; NaNO₂

5: concentrated aqueous HCl

With hydrogenchloride; hydrazine hydrate; sodium nitrite;

DOI:10.1002/ardp.19362740405

Reference yield:

6-bromo-2-phenyl-quinoline-4-carboxylic acid hydrazide (304664-08-2) → 6-bromo-2-phenyl-[4]quinolylamine (856046-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous HCl; NaNO₂

3: concentrated aqueous HCl

With hydrogenchloride; sodium nitrite;

DOI:10.1002/ardp.19362740405

upstream raw materials:

(6-bromo-2-phenyl-[4]quinolyl)-carbamic acid ethyl ester

6-bromo-2-phenyl-quinoline-4-carboxylic acid

6-bromo-2-phenyl-quinoline-4-carboxylic acid hydrazide

ethyl 6-bromo-2-phenylquinoline-4-carboxylate