FMOC-D-PRO-CL

Base Information

• Chemical Name: FMOC-D-PRO-CL
• CAS No.: 171905-37-6
• Molecular Formula: C20H18ClNO3
• Molecular Weight: 355.821
• Mol file: 171905-37-6.mol

Synonyms:FMOC-D-PRO-CL;FMOC-D-PROLYL CHLORIDE;NALPHA-9-Fluorenylmethoxycarbonyl-D-prolyl chloride

Chemical Property of FMOC-D-PRO-CL

Chemical Property:

• PSA: 46.61000
• LogP: 4.10320
• Storage Temp.: Store at 0°C

Purity/Quality:

98.5% ^*data from raw suppliers

Fmoc-D-prolyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-PRO-CL

There total 1 articles about FMOC-D-PRO-CL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester (71989-31-6,109425-54-9,144829-96-9,101555-62-8) → (R)-(9H-fluorene-9-yl)methyl 2-(chlorocarbonyl)pyrrolidine-1-carboxylate (171905-37-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 90.0%

benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate (1241833-16-8) + (R)-(9H-fluorene-9-yl)methyl 2-(chlorocarbonyl)pyrrolidine-1-carboxylate (171905-37-6) → (9H-fluoren-9-yl)methyl (R)-2-((3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)(4-cyclohexylbenzyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00544

Reference yield: 71.0%

rac-N’-cyano-3-(3,4-dichlorophenyl)-N-[3-(difluoromethoxy)phenyl]-4-(ethylamino)-4,5-dihydro-1H-pyrazole-1-carboximidamide + (R)-(9H-fluorene-9-yl)methyl 2-(chlorocarbonyl)pyrrolidine-1-carboxylate (171905-37-6) → 9H-fluoren-9-ylmethyl (2R)-2-{[1-{N'-cyano-N-[3-(difluoromethoxy)phenyl]carbamimidoyl}-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl](ethyl)carbamoyl}pyrrolidine-1-carboxylate

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 0.166667h;

upstream raw materials:

(R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Downstream raw materials:

C₂₇H₂₄N₂O₅

Demethoxyfumitremorgin C

Refernces

• 1、 -. "2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS". Paragraph 00462. . Retrieved 2018/08/20.
• 2、 Chaume, Grégory,Simon, Julien,Lensen, Nathalie,Pytkowicz, Julien,Brigaud, Thierry,Miclet, Emeric. "Homochiral versus Heterochiral Trifluoromethylated Pseudoproline Containing Dipeptides: A Powerful Tool to Switch the Prolyl-Amide Bond Conformation". . p. 13602 - 13608. Retrieved 2017/12/26.