Technology Process of 4-ethyl-3-iodobenzaldehyde
There total 1 articles about 4-ethyl-3-iodobenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-iodo-succinimide; trifluoroacetic acid;
at 20 ℃;
for 16h;
regioselective reaction;
DOI:10.1002/ejoc.201700173
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.33 h / 0 °C
1.2: 20 °C
2.1: copper(I) trifluoromethanesulfonate benzene; 2,2′-isopropylidenebis[(4R)-4-tert-butyl-2-oxazoline] / 1,2-dichloro-ethane / 24 h / -15 °C
3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; dimethyl sulfoxide / 50 - 80 °C / Inert atmosphere
With
potassium acetate; potassium hexamethylsilazane;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; copper(I) trifluoromethanesulfonate benzene; 2,2′-isopropylidenebis[(4R)-4-tert-butyl-2-oxazoline];
In
tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.33 h / 0 °C
1.2: 20 °C
2.1: copper(I) trifluoromethanesulfonate benzene; 2,2′-isopropylidenebis[(4R)-4-tert-butyl-2-oxazoline] / 1,2-dichloro-ethane / 24 h / -15 °C
With
potassium hexamethylsilazane;
copper(I) trifluoromethanesulfonate benzene; 2,2′-isopropylidenebis[(4R)-4-tert-butyl-2-oxazoline];
In
tetrahydrofuran; 1,2-dichloro-ethane;
