2,5-Dimethyl-1,2-dihydropyridine-2-carboxamide

Base Information

• Chemical Name: 2,5-Dimethyl-1,2-dihydropyridine-2-carboxamide
• CAS No.: 825-59-2
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• DSSTox Substance ID: DTXSID90703098
• Mol file: 825-59-2.mol

Synonyms:825-59-2;2,5-Dimethyl-pyridineformamide;2,5-Dimethyl-1,2-dihydropyridine-2-carboxamide;2,5-dimethyl-1H-pyridine-2-carboxamide;2,5-Dimethylpyridineformamide;DTXSID90703098

Chemical Property of 2,5-Dimethyl-1,2-dihydropyridine-2-carboxamide

Chemical Property:

• PSA: 45.48000
• LogP: 1.91620
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 152.094963011
• Heavy Atom Count: 11
• Complexity: 243

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dimethyl-pyridineformamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CNC(C=C1)(C)C(=O)N

Technology Process of 2,5-Dimethyl-1,2-dihydropyridine-2-carboxamide

There total 2 articles about 2,5-Dimethyl-1,2-dihydropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dimethyl-2-(pivaloylamino)-pyridine (1313762-34-3) → N-(3,6-dimethyl-pyridin-2-yl)-formamide (825-59-2)

Guidance literature:

3,6-dimethyl-2-(pivaloylamino)-pyridine; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - -30 ℃; for 5h; Inert atmosphere;

With N,N-dimethyl-formamide; In diethyl ether; pentane; at -30 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.02.037

Reference yield:

→ N-(3,6-dimethyl-pyridin-2-yl)-formamide (825-59-2)

Guidance literature:

2-Amino-3,6-dimethyl-pyridin, Ameisensaeure, Ac2O, Ae., Raumtemp., 2 d;

Reference yield:

N-(3,6-dimethyl-pyridin-2-yl)-formamide (825-59-2) → 6-methyl-1H-pyrrolo<2,3-b>pyridine (824-51-1)

Guidance literature:

With hydrogenchloride; In diethyl ether; water; pentane; at -20 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2009.02.037

upstream raw materials:

3,6-dimethyl-2-(pivaloylamino)-pyridine

Downstream raw materials:

6-methyl-1H-pyrrolo<2,3-b>pyridine

Refernces