6,8-Dioxabicyclo[3.2.1]octane,2-fluoro-1,5-dimethyl-,(1S,2S,5S)-(9CI)

Base Information

Chemical Name:6,8-Dioxabicyclo[3.2.1]octane,2-fluoro-1,5-dimethyl-,(1S,2S,5S)-(9CI)
CAS No.:281193-52-0
Molecular Formula:C₈H₁₃FO₂
Molecular Weight:160.188
Hs Code.:
Mol file:281193-52-0.mol

Synonyms:6,8-Dioxabicyclo[3.2.1]octane,2-fluoro-1,5-dimethyl-,(1S,2S,5S)-(9CI)

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Chemical Property of 6,8-Dioxabicyclo[3.2.1]octane,2-fluoro-1,5-dimethyl-,(1S,2S,5S)-(9CI)

Chemical Property:

Purity/Quality:

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Technology Process of 6,8-Dioxabicyclo[3.2.1]octane,2-fluoro-1,5-dimethyl-,(1S,2S,5S)-(9CI)

There total 5 articles about 6,8-Dioxabicyclo[3.2.1]octane,2-fluoro-1,5-dimethyl-,(1S,2S,5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,2R,5S)-1-sulfenylmethyl-2-fluorofrontalin

: 281193-50-8,281193-52-0,281193-45-1,281193-53-1
(+)-(1S,2R,5S)-2-fluorofrontalin

Guidance literature:: With hydrogen; nickel; In ethylene glycol; at 125 ℃; for 24h;
DOI:10.1002/(SICI)1099-0690(200004)2000:8<1387::AID-EJOC1387>3.0.CO;2-G

Reference yield:

: (3R,R_S)-3-fluoro-1-[(4-methylphenyl)sulfinyl]hept-6-en-2-one

: 281193-50-8,281193-52-0,281193-45-1,281193-53-1
(+)-(1S,2R,5S)-2-fluorofrontalin

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 0 °C

2: HClO₄ / tetrahydrofuran; H₂O / 40 °C

3: PdCl₂; CuCl₂; O₂ / bis-(2-methoxy-ethyl) ether / 20 °C

4: NaI; (CF₃CO)2O / acetone / -20 °C

5: H₂ / Raney-Ni / ethane-1,2-diol / 24 h / 125 °C

With perchloric acid; hydrogen; oxygen; trifluoroacetic anhydride; sodium iodide; copper dichloride; palladium dichloride; nickel; In tetrahydrofuran; methanol; diethylene glycol dimethyl ether; water; ethylene glycol; acetone; 1: methylene insertion / 2: Addition / 3: Oxidation / 4: Reduction / 5: Hydrogenolysis;
DOI:10.1002/(SICI)1099-0690(200004)2000:8<1387::AID-EJOC1387>3.0.CO;2-G

Reference yield:

: (S)-2-((R)-1-Fluoro-pent-4-enyl)-2-((R)-toluene-4-sulfinylmethyl)-oxirane

: 281193-50-8,281193-52-0,281193-45-1,281193-53-1
(+)-(1S,2R,5S)-2-fluorofrontalin

Guidance literature:: Multi-step reaction with 4 steps

1: HClO₄ / tetrahydrofuran; H₂O / 40 °C

2: PdCl₂; CuCl₂; O₂ / bis-(2-methoxy-ethyl) ether / 20 °C

3: NaI; (CF₃CO)2O / acetone / -20 °C

4: H₂ / Raney-Ni / ethane-1,2-diol / 24 h / 125 °C

With perchloric acid; hydrogen; oxygen; trifluoroacetic anhydride; sodium iodide; copper dichloride; palladium dichloride; nickel; In tetrahydrofuran; diethylene glycol dimethyl ether; water; ethylene glycol; acetone; 1: Addition / 2: Oxidation / 3: Reduction / 4: Hydrogenolysis;
DOI:10.1002/(SICI)1099-0690(200004)2000:8<1387::AID-EJOC1387>3.0.CO;2-G