4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid

Base Information

Chemical Name:4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid
CAS No.:408366-18-7
Molecular Formula:C14H9F3O3
Molecular Weight:282.219
Hs Code.:2918990090
European Community (EC) Number:673-785-6
DSSTox Substance ID:DTXSID30375319
Wikidata:Q72511366
Mol file:408366-18-7.mol

Synonyms:408366-18-7;4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid;2-(4-Trifluoromethoxyphenyl)benzoic acid;2-[4-(trifluoromethoxy)phenyl]benzoic Acid;4'-Trifluoromethoxy-biphenyl-2-carboxylic acid;4'-trifluoromethoxybiphenyl-2-carboxylic acid;4'-(Trifluoromethoxy)-biphenyl-2-carboxylic acid;SCHEMBL5937086;DTXSID30375319;JPLHXHHURMRLGR-UHFFFAOYSA-N;AMY20957;MFCD04117417;BS-28161;CS-0205044;4'-(trifluoromethoxy)biphenyl-2-carboxylic acid;A825311;4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylicacid;4'-(Trifluoromethoxy)[1,1'-biphenyl]-2-carboxylic acid

Suppliers and Price of 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylicacid 95+%
10g
$ 564.00

Crysdot
4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylicacid 95+%
5g
$ 339.00

American Custom Chemicals Corporation
4'-TRIFLUOROMETHOXY-BIPHENYL-2-CARBOXYLIC ACID 95.00%
1G
$ 253.05

Alichem
4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylicacid
10g
$ 558.60

AK Scientific
2-(4-Trifluoromethoxyphenyl)benzoicacid
1g
$ 211.00

AHH
4-Trifluoromethoxybiphenyl-2-carboxylicacid 98%
1g
$ 280.00

Acrotein
4'-(Trifluoromethoxy)-biphenyl-2-carboxylicacid 97%
0.5g
$ 103.03

Total 15 raw suppliers

Chemical Property of 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid

Chemical Property:

PSA：46.53000
Density:1.359±0.06 g/cm3 (20 ºC 760 Torr)
LogP:3.95040
Storage Temp.:2-8°C
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:282.05037863
Heavy Atom Count:20
Complexity:335

Purity/Quality:

97% ^*data from raw suppliers

4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=CC=C(C=C2)OC(F)(F)F)C(=O)O

Technology Process of 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid

There total 4 articles about 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 4'-trifluoromethoxybiphenyl-2-carboxylate

: 408366-18-7
4’-(trifluoromethoxy)[1,1’-biphenyl]-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 80 ℃;
DOI:10.1002/chem.201303511

Reference yield:

: 610-97-9
o-iodo-methyl-benzoic acid

: 408366-18-7
4’-(trifluoromethoxy)[1,1’-biphenyl]-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 - 80 °C / Schlenk technique; Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate; sodium hydroxide; In tetrahydrofuran; water; 1: |Suzuki Coupling;
DOI:10.1002/chem.201303511

Reference yield:

: 139301-27-2
4-trifluoromethoxyphenylboronic acid

: 408366-18-7
4’-(trifluoromethoxy)[1,1’-biphenyl]-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 20 - 80 °C / Schlenk technique; Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; water; sodium carbonate; sodium hydroxide; In tetrahydrofuran; water; 1: |Suzuki Coupling;
DOI:10.1002/chem.201303511